实体瘤免疫治疗疗效评价标准

免疫治疗已经成为实体瘤除手术、放疗、化疗、靶向治疗之外的重要治疗手段。然而免疫治疗的作用机制不同于既往的治疗手段，它是通过激活机体的免疫效应而杀伤肿瘤细胞，达到肿瘤负荷的下降及生存期延长的目的。所以传统的世界卫生组织（WHO）疗效评价标准和实体瘤疗效评价标准（RECIST）也就很难对肿瘤免疫治疗的临床疗效进行准确解读，新的免疫疗效评价标准则涵盖了免疫疗效的各种表现形式，正逐渐应用于临床。

Efficacy evaluation criteria for immunotherapy in solid tumors

Immunotherapy has become an important therapy for solid tumors,which is in addition to surgery,radiotherapy,chemotherapy and targeted therapy.However immune treatment mechanism is different from those previous treatment.The effect of immunotherapies is on the immune system and not directly on the tumor.The kinetics of immunotherapy is characterized by a cellular immune response followed by potential changes in tumor burden and survival period.They are not captured by the traditional World Health Organiza-tion (WHO)or the Response Evaluation Criteria in Solid Tumors (RECIST).New immune-related response criteria are defined which more comprehensively capture all response patters and gradually applied in clinical practice.