舒肝解郁胶囊联用多潘立酮片治疗功能性消化不良临床研究

目的：评价舒肝解郁胶囊与多潘立酮片联用治疗功能性消化不良(functional dyspepsia, FD)的疗效。方法将符合入选标准的84例FD患者采用随机数字表法分为2组各42例，对照组口服多潘立酮片，观察组在对照组基础上联用舒肝解郁胶囊。2组均治疗4周。超声测定近端胃容积和胃底气体评分。X 射线钡条胶囊检测胃排空率，评价临床疗效并观察治疗期间的不良反应。结果观察组总有效率为90.5%(38/42)、对照组为76.2%(32/42)，2组比较差异有统计学意义(χ2＝2.254，P＝0.043)。治疗后，观察组饮水60 min时[(15.52±3.21)ml比(23.54±5.11)ml，t＝2.412]胃容积显著小于对照组(P＜0.05)；观察组气体评分[(0.42±0.13)分比(0.64±0.16)分，t＝2.384]的降低及胃排空率[(74.15±11.62)%比(54.82±10.31)%，t＝2.324]的增加均优于对照组(P＜0.05)。结论舒肝解郁胶囊可促进FD患者胃排空，改善胃肠动力，疗效优于单纯口服多潘立酮片治疗。

The clinical effect of Shugan-Jieyu capsule combined with domperidone on functional dyspepsia

Objective To observe the clinical effect ofShuganJieyu capsule combined with domperidone on functional dyspepsia (FD).Methods84 FD patients were recruited in this study. The patients were divided into the control group (n=42) and the observation group (n=42). Control group was treated with domperidone, and observation group was treated with combination ofShuganJieyu capsule and domperidone. Both groups were treated for 4 weeks. The gastric volume, gastric gas scores, and gastric emptying rates were detected by the ultrasound and X-ray. The clinical effect and adverse reactions was compared.ResultsThe clinic effective rate of observation group was 90.5% (38/42), and the control group was 76.2% (32/42). After treatment, the gastric volume of 60 min was significantly lower in observation group than that in control group (15.52 ± 3.21 mlvs. 23.54 ± 5.11 ml;t=2.412,P<0.05); the decreasing of gastric gas scores (0.42 ± 0.13vs. 0.64 ± 0.16;t=2.384,P<0.05) and increasing of gastric emptying rate (74.15% ± 11.62%vs. 54.82% ± 10.31%;t=2.324,P<0.05) were significantly higher in observation group than those in control group.ConclusionShugan-Jieyu capsule can improve gastric emptying and gastrointestinal motility, and showed better effect than domperidone alone.