冠心舒通胶囊对高血压病患者大动脉弹性的影响

目的：探讨冠心舒通胶囊对高血压病患者大动脉弹性的影响。方法将符合入选标准的高血压病患者按随机数字表法分为治疗组(50例)和对照组(52例)，对照组口服降压药使血压控制在正常范围；治疗组在对照组基础上加用冠心舒通胶囊。2组均治疗8周。采用自动脉搏波速度分析仪测定颈-股动脉搏波传导速度(carotid- femoral pulse wave velocity, C-FPWV)、颈-足背动脉搏波传导速度(cervical-dorsal arterial pulse wave velocity, C-DPWV)评估大动脉弹性；采用增强免疫比浊法测定超敏C反应蛋白(high sensitivity Creactiveprotein, hs-CRP)；采用放射免疫法检测血清IL-6、TNF-a；采用全自动生化分析仪测定TG、TC，治疗期间监测患者血压。结果治疗后，治疗组hs-CRP[(2.83±1.35)mg/L比(3.65±1.38)mg/L，t＝6.357]、TNF-α[(0.16±0.08)mg/L 比(0.28±0.07)mg/L，t＝18.213]水平明显低于对照组(P＜0.01)；C-FPWV[(13.85±1.86)m/s比(15.34±1.78)m/s，t＝6.524]、C-DPWV[(11.98±1.45)m/s比(12.87±1.48)m/s，t＝7.152]明显低于对照组(P＜0.01)。治疗后，2组收缩压均降至临界状态，舒张压恢复正常。结论冠心舒通胶囊可通过抑制系统性炎症，减轻、逆转动脉粥样硬化，改善高血压病患者大动脉弹性及血压水平。

Effect and mechanism of Guanxin-Shutongcapsule in the treatment of arterial elasticity on the patients with hypertension

Objective To observe the effect ofGuanxin-Shutongcapsule in the treatment of arterial elasticity on patients with hypertension.Methods The hypertension patients who met the inclusion criteria were divided into treatment group (50 cases) and control group (52 cases). The control group was treated with antihypertensive drugs to control blood pressure within the normal range. The treatment group was treated withGuanxin-Shutongcapsule on the basis of the control group. All were given 8 weeks treatment. The main artery elastic parameters were meansured by the carotid-femoral pulse wave velocity (C-FPWV) and cervical-dorsal arterial pulse wave velocity (C-DPWV). The immune turbidimetric method was employed to enhance for the determination of high sensitive C reactive protein (hs-CRP); and radioimmunoassay was used to assess the serum IL-6, TNF-a, triglyceride (TG) and total cholesterol (TC). The blood pressure was monitored during the treatment.Results After the treatment, the level of hs-CRP (2.83 ± 1.35 mg/Lvs. 3.65 ± 1.38 mg/L,t=6.357), TNF-α (0.16 ± 0.08 mg/Lvs. 0.28 ± 0.07 mg/L,t=18.213), C-FPWV (13.85 ± 1.86 m/svs. 15.34 ± 1.78 m/s,t=6.524), C-DPWV (11.98 ± 1.45 m/svs. 12.87 ± 1.48 m/s,t=7.152) in treatment group was significantly lower than those in the control group (P<0.01).ConclusionGuanxin-Shutong capsule by inhibiting systemic inflammation, reducing and reversing atherosclerosis, and improving the arterial elasticity and blood pressure.