芍药甘草颗粒对利培酮所致的女性精神分裂症高催乳素血症患者血清催乳素水平的影响

目的：探讨芍药甘草颗粒对利培酮所致的女性精神分裂症高催乳素血症患者血清催乳素水平的影响。方法将符合入选标准的100例女性精神分裂症患者采用随机数字表法分为2组，每组50例。对照组口服利培酮治疗，观察组在对照组基础上联用芍药甘草颗粒。2组均治疗12周。采用免疫化学发光法检测血清催乳素、雌激素水平，采用阳性及阴性症状量表(Positive and Negative Syndrome Scale, PANSS)评价患者的精神症状。结果治疗后，观察组血清催乳素(46.28±14.06)ng/ml比(117.89±22.11)ng/ml，t＝10.242]水平明显低于对照组(P＜0.01)。观察组治疗后 PANSS 评分(67.45±7.00)分比(96.53±11.88)分，t＝7.125]、对照组 PANSS 评分(68.73±7.71)分比(97.93±12.65)分，t＝6.541]均较同组治疗前降低(P＜0.01)，但2组治疗后比较，差异均无统计学意义(t＝0.682，P＞0.05)。结论芍药甘草颗粒可降低利培酮所致的精神分裂症高催乳素血症患者的血清催乳素水平，且不影响其体内雌激素水平。

The effect ofShaoyao-Gancao grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone

Objective To study the effect of Shaoyao Gancao Grain on serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone.Methods 100 patients were randomly divided into the control group 50 cases,which were given risperidone. The study group 50 cases,which were given Shaoyao Gancao Grain on the basis of the control group. The two groups were treated for 12 weeks. Positive And Negative Syndrome Scale,serum prolactin and Estrogen level were measured by immunohistochemistry before and after 12 weeks of treatenmt.Results After 12 weeks of treatenmt,serum prolactin levels were decreased in the study group than control group (46.28 ± 14.06 ng/mlvs. 117.89 ± 22.11 ng/ml;t=10.242,P<0.01). PANSS score were decreased in the study group copare with before treatenmt (67.45 ± 7.00vs. 96.53 ± 11.88;t=7.125,P<0.01). PANSS score were decreased in the control group copare with before treatenmt (68.73 ± 7.71vs. 9 7.93 ± 12.65;t=6.541,P<0.01). But there were no difference in PANSS score between the two groups after treatenmt (t=0.682,P>0.05). ConclusionsShaoyao-Gancao grain can decrease serum prolactin level in female schizophrenia patients with high prolactin induced by risperidone,does not affect estrogen levels.