| 胶质瘤干细胞的分子靶向治疗 |
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| 引用本文： | 童鹿青,汤天娇,杨学军. 胶质瘤干细胞的分子靶向治疗[J]. 国际肿瘤学杂志, 2016, 0(12): 930-934. DOI: 10.3760/cma.j.issn.1673-422X.2016.12.013 |
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| 作者姓名： | 童鹿青 汤天娇 杨学军 |
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| 作者单位： | 1. 300052,天津医科大学总医院神经外科;2. 重庆医科大学附属第一医院肿瘤科 |
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| 基金项目： | 国家自然科学基金(81472352);天津市应用基础与前沿技术研究计划(15JCZDJC36200)Fund programNational Natural Science Foundation of China (81472352);Tianjin Research Program of Application Foundation and Advanced Technology (15JCZDJC36200) |
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| 摘 要： | 胶质瘤干细胞（GSC）被认为是恶性胶质瘤迁移、复发和放化疗抵抗的根源。结合分子靶向药物在其他肿瘤领域走向临床的背景,针对 GSC 的分子靶向药物有望取得成功。目前,相关研究主要集中在 Hedgehog、PI3K 等通路,代表药物主要有环巴胺及其衍生物、雷帕霉素及其衍生物,经典药物三氧化二砷、二甲双胍也有抗 GSC 作用。
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| 关 键 词： | 神经胶质瘤 干细胞 分子靶向治疗 |
Molecular targeted therapy for glioma stem cells |
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| Abstract: | Glioma stem cells (GSCs)are considered to be the root of migration,recurrence,and re-sistance to chemo-radiotherapy in malignant glioma.With molecular targeting drugs becoming widespread in treating other cancers,the ones targeting GSCs could also be successful in the future.At present,relevant stu-dies mainly concentrate in the hedgehog and PI3K pathways,and main representative drugs are cyclopamine and its derivatives,rapamycin and its derivatives,and some classical drugs like arsenic trioxide and metformin also performing the outcome of anti-GSCs. |
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| Keywords: | Glioma Stem cells Molecular targeted therapy |
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