痰热清注射液结合西医常规疗法治疗老年支气管肺炎临床研究

目的：评价痰热清注射液结合西医常规疗法治疗老年支气管肺炎患者的疗效。方法将符合入选标准的146例老年支气管肺炎患者按随机数字表法分为2组，每组73例。对照组采用西医常规疗法治疗，治疗组在对照组基础上静滴痰热清注射液。2组均治疗7 d。采用流式细胞仪检测患者外周血Th17和Treg细胞比例，ELISA法测定IL-17、IL-10、IL-6和TNF-α因子表达，评价临床疗效。结果对照组总有效率为79.5%(58/73)、治疗组为91.8%(67/73)，2组比较差异有统计学意义(χ2＝2.406，P＝0.045)。治疗后，治疗组Th17细胞(5.16±1.24)%比(8.22±1.84)%；t＝2.564，P＝0.017]低于对照组、Treg 细胞(6.32±1.79)%比(4.32±1.23)%；t＝2.552，P＝0.021]高于对照组；治疗组 IL-17(11.43±2.52)ng/ml比(14.15±2.61)ng/ml，t＝2.684]、IL-6(12.47±2.16)ng/ml比(15.58±3.12)ng/ml，t＝2.564]、TNF-α(25.43±4.27)ng/ml 比(32.55±6.14)ng/ml，t＝2.594]水平低于对照组(P＜0.05)，IL-10(10.07±2.13)ng/ml 比(7.94±1.83)ng/ml；t＝2.673，P＝0.023]高于对照组。对照组体温消退时间(4.57±1.24)d比(3.25±0.92)d，t＝2.628]、咳嗽消失时间(7.53±2.13)d 比(6.14±1.59)d，t＝2.416]、肺部啰音消失时间(6.81±1.82)d 比(5.17±1.06)d，t＝2.537]均较治疗组延迟(P＜0.05)。结论痰热清注射液结合西医常规疗法可调节老年支气管肺炎患者体内Th17/Treg细胞的平衡，提高临床疗效。

The clinical effect ofTanreqing injection combined with routine western medicine on the treatment of senile bronchial pneumonia

Objective To observe the effect ofTanreqinginjection combined with routine medicines on the treatment of senile patients with bronchial pneumonia.Methods A total of 146 patients were randomly divided into 2 groups according to the random number table, each group 73 patients. Control group was treated with routine medicines and treatment group was added 20 mlTanreqing once a day. All treatments lasta total of 7 days. The Th17 and Treg cells were detected by cytometry analysis. The expression of IL-17, IL-10, IL-6, and TNF-α were detected by ELISA analysis. The clinical effect and adverse effect of the two groups were compared. Results After treatment, the clinical effective rate of control group was 79.5% (58/73), which was significantly lower than that of 91.8% (67/73) in treatment group (χ2=2.406,P=0.045). After treatment, Th17 cells was significantly lower in the treatment group than that in the control group (5.16% ± 1.24%vs. 8.22% ± 1.84%;t=2.564,P=0.017); but Treg cells was significantly higher in the treatment group than that in the control group (6.32% ± 1.79%vs. 4.32% ± 1.23%;t=2.552,P=0.021). The expression of IL-17 (11.43 ± 2.52 ng/mlvs. 14.15 ± 2.61 ng/ml,t=2.684), IL-6 (12.47 ± 2.16 ng/mlvs. 15.58 ± 3.12 ng/ml,t=2.564), and TNF-α (25.43 ± 4.27 ng/ml vs. 32.55 ± 6.14 ng/ml,t=2.594) was significantly lower in the treatment group than those in the control group. However, the expression of IL-10 (10.07 ± 2.13 ng/mlvs. 7.94 ± 1.83 ng/ml;t=2.673,P=0.023) was significantly higher in the treatment group than that in the control group. The temperature decreased time (4.57 ± 1.24 dvs.
3.25 ± 0.92 d,t=2.628), cough disappeared time (7.53 ± 2.13 dvs.6.14 ± 1.59 d,t=2.416), pulmonary rales disappeared time (6.81 ± 1.82 dvs.5.17 ± 1.06 d,t=2.537) was significantly lower in the treatment group than those in the control group.Conclusions TheTanreqing injection combined with routine western medicine could regulate Th17/Treg cells balance in the senile patients with bronchial pneumonia, and showed the significantly clinical effect.