| HER-2阴性胃癌的分子靶向治疗 |
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| 引用本文： | 彭湃,易善永,赵玲. HER-2阴性胃癌的分子靶向治疗[J]. 国际肿瘤学杂志, 2016, 0(12): 943-946. DOI: 10.3760/cma.j.issn.1673-422X.2016.12.016 |
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| 作者姓名： | 彭湃 易善永 赵玲 |
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| 作者单位： | 450007,郑州大学附属郑州中心医院肿瘤科 |
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| 基金项目： | 郑州市科技攻关项目(20140449)Fund programScience and Technology Project of Zhengzhou City (20140449) |
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| 摘 要： | 目前分子靶向治疗已成为胃癌研究领域的热点。人类表皮生长因子受体-2（HER-2）靶基因的发现及相关靶向治疗已在临床广泛应用，而 HER-2阳性的发病人群＜20％。除 HER-2外，针对肿瘤细胞生长、浸润及血管生成等的靶点和靶向治疗值得关注。一些分子靶向药物应用于临床并呈现良好的疗效，为 HER-2阴性胃癌患者带来希望。
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| 关 键 词： | 胃肿瘤 受体,表皮生长因子 分子靶向治疗 |
Molecular targeted therapy for HER-2 negative gastric cancer |
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| Abstract: | Molecular targeted treatment has become hotspot in the gastric cancer research.Human epi-dermal growth factor receptor-2(HER-2)target genes found to treatment has widely used in clinical practice, and HER-2 positive incidence of less than 20%.In addition to HER-2,understanding the molecular pathways that characterize in cell growth,invasion and angiogenesis of targets and targeted therapy are worthy for atten-tion.There are some molecular targeted drugs have been used to treat tumors,and patients can benefit from the treatment which brings new hope for patients with HER-2 negative gastric cancer. |
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| Keywords: | Stomach neoplasms Receptor,epidermal growth factor Molecular targeted therapy |
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