| 基于纳滤分离优势优化丹参注射液的生产浓缩工艺 |
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| 引用本文： | 李存玉,马赟,陈涛,李红阳,彭国平.基于纳滤分离优势优化丹参注射液的生产浓缩工艺[J].国际中医中药杂志,2016(6):543-545. |
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| 作者姓名： | 李存玉 马赟 陈涛 李红阳 彭国平 |
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| 作者单位： | 1. 210023 南京中医药大学药学院; 210023 南京，江苏省中药资源产业化过程协同创新中心;2. 210023,南京中医药大学药学院 |
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| 基金项目： | 国家自然科学基金(81503258)；江苏省自然科学基金青年基金(BK20151005)；江苏省中医药局科技项目(YB2015009)；南京中医药大学新专业建设专项课题(NZYXZY2013-05) |
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| 摘 要： | 目的：优化丹参注射液生产过程中的浓缩工艺。方法以酚酸类成分丹参素钠、原儿茶醛、丹酚酸B的保留率为指标，分析常压、减压、纳滤、纳滤-减压浓缩在丹参提取液浓缩工序中的可行性。结果常压和减压浓缩影响酚酸成分组成；纳滤浓缩无明显影响，成分保留率均大于93%，但药液比重和黏度影响浓缩效率；纳滤-减压联用浓缩，成分保留率大于91%，对物质组成影响不明显。结论纳滤在含有热敏性成分的中药药液浓缩中技术优势明显，应用前景广阔。
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| 关 键 词： | 丹参注射液 纳滤 浓缩 中药工艺改进 |
To optimize the concentrate process ofDanshen injection by nanofiltration technique |
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| Abstract: | Objective To optimize the concentrate process ofDanshen injection.Methods The concentration changes of Salvianic acid A sodium, Protocatechuic aldehyde and Salvianolic acid B were selected as indexes to compare mospheric concentrate, vacuum concentrate, nanofiltration concentrate and nanofiltration-vacuum coupling concentrate methods with HPLC. Results Phenolic acid composition changed when atmospheric and vacuum concentrate method were used. Retention rate of three phenolic acids were over 93% after nanofiltration concentration, but the concentration efficiency was limited by solution viscosity. Nanofiltration-vacuum coupling concentrate methods could solve the above problems, meanwhile, retention rate of three phenolic acids were over 91%.Conclusions Nanofiltration technology takes advantage in medicine extraction concentrate with heat sensitive ingredients, and its application prospect in traditional Chinese medicine pharmaceutical industry would be broad. |
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| Keywords: | Dan shen zhu she ye Nanofiltration Concentrate process Technology improving (TCD) |
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