鱼白桑止咳方治疗慢性支气管炎患者128例疗效观察

目的：评价鱼白桑止咳方对慢性支气管炎(chronic bronchitis, CB)急性发作患者的临床疗效。方法将符合入选标准的128例CB急性发作患者按随机数字表法分为2组，对照组63例采用西医常规疗法治疗，治疗组在对照组基础上加服鱼白桑止咳方。均治疗7 d。观察2组治疗前后症状、体征及影像学变化，记录化验室指标的改变，评价临床疗效。结果治疗组总有效率[92.58%(60/65)比79.37%(50/63)]，高于对照组(χ2＝4.434，P＝0.035)。治疗组止咳时间[(3.28±1.21)d比(5.77±1.45)d， t＝10.562]、平喘时间[(8.02±3.29)d比(10.83±7.17)d，t＝2.864]、痰液恢复正常时间[(3.27±1.18)d比(5.18±1.16)d，t＝9.232]、肺部啰音消失时间[(4.53±1.27)d比(7.96±1.45)d，t＝14.249]均较对照组缩短(P＜0.05)。治疗后，治疗组 WBC[(5.9±2.7)×109/L 比(8.1±2.6)×109/L，t＝4.693]、中性粒细胞计数[(63.3±6.1)%比(69.2±6.5)%，t＝5.297]、CRP[(14.5±5.9)mg/L比(18.4±4.8)mg/L，t＝4.095]均低于对照组(P＜0.05)。结论鱼白桑止咳方加减配合西医常规疗法，可提高CB急性发作患者总体疗效，缓解临床症状，缩短病程，疗效优于单纯西医常规疗法。

Clinical observation of Yubaisang-Zhikefang decoction on treating 128 patients withchronic bronchitis

Objective To observe effects of theYubaisang-Zhikefangdecoction on chronic bronchitis.MethodsA total of 128 patients were randomly divided into two groups. The control group was given the conventional therapy, and the treatment group was added theYubaisang-Zhikefang decoction based on the conventional therapy.ResultsThe total effective rate of treatment group was significantly better than the control group (92.58%vs. 79.37%;χ2=4.434,P=0.035). The treatment group significantly improved the symptoms of time of cough disappearance(3.28 ± 1.21 d vs. 5.77 ± 1.45 d;t=10.562,P<0.05), time of asthma stop (8.02 ± 3.29d vs. 10.83 ± 7.17 d;t=2.864,P<0.05), time of sputum disappearance (3.27 ± 1.18d vs. 5.18 ± 1.16 d;t=9.232,P<0.05), time of moist sounds disappearance(4.53 ± 1.27 vs. 7.96 ± 1.45 d;t=14.249, P<0.05). And the treatment group significantly improved the results of blood tests and lung imaging, like the WBC (5.9×109/L ± 2.7×109/L vs. 8.1×109/L ± 2.6×109/L;t=4.693,P<0.05), N% (63.3% ± 6.1% vs. 69.2% ± 6.5%;t=-4.68,P<0.05), CRP (14.5 ± 5.9 mg/L vs. 18.4 ± 4.8 mg/L;t=5.297,P<0.05).ConclusionThe integrated treatment ofYubaisang-Zhikefangdecoction plus convertional the rapy showed good effects on the patients with chronic bronchitis.