Trefoil factors in inflammatory bowel disease |
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Authors: | Luise Aamann Else Marie Vestergaard Henning Gr?nb?k |
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Institution: | Luise Aamann;Else Marie Vestergaard;Henning Grφnbk;Department of Hepatology and Gastroenterology,Aarhus University Hospital;Department of Clinical Genetics,Aarhus University Hospital; |
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Abstract: | Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn’s disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD. |
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Keywords: | Trefoil factors Inflammatory bowel disease Ulcerative colitis Crohn’s disease Inflammation |
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