| 用PCR-SSP方法分析南方汉族人群MICA基因多态性 |
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| 引用本文： | 龚卫娟,曹春育,姚玲,刘丹,田芳,季明春.用PCR-SSP方法分析南方汉族人群MICA基因多态性[J].实用临床医药杂志,2006,10(1):29-33. |
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| 作者姓名： | 龚卫娟 曹春育 姚玲 刘丹 田芳 季明春 |
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| 作者单位： | 扬州大学医学院病原生物学和免疫学教研室,江苏,扬州,225001 |
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| 基金项目： | 国家自然科学基金(30400399)，扬州大学科研基金(PK0313100) |
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| 摘 要： | 目的调查南方汉族人群MICA基因外显子2~6的多态性。方法采用聚合酶链反应/序列特异性引物(PCR-SSP)方法,调查113例江苏省扬州地区汉族正常人群MICA等位基因的分布情况。结果共检测出18个MICA等位基因,最常见的3种等位基因分别是MICA*008(23.0%),MICA*010(17.6%)和MICA*002/020(11.2%),最罕见的3种等位基因是MICA*042(0.4%),MICA*045(1.3%)和MICA*044(1.3%)。结论中国南方汉族人群MICA等位基因分布频率具有自己的种族特异性。
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| 关 键 词： | PCR/SSP MICA 多态性 |
| 文章编号： | 1672-2353（2006）01-0029-05 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005年9月12日 |
ANALYSIS OF POLYMORPHISM OF MICA GENE IN CHINESE SOUTH HAN POPULATION |
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| GONG We-juan,CAO Chun-yu,YAO Ling,LIU Dan,TIAN Fang,JI Ming-chun.ANALYSIS OF POLYMORPHISM OF MICA GENE IN CHINESE SOUTH HAN POPULATION[J].Journal of Clinical Medicine in Practice,2006,10(1):29-33. |
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| Authors: | GONG We-juan CAO Chun-yu YAO Ling LIU Dan TIAN Fang JI Ming-chun |
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| Abstract: | Objective To investigate the polymorphism of MICA gene from exon 2 to exon 6 in Chinese south Han population.Methods MICA alleles were assigned by using a PCR/SSP method in 113 random healthy individuals from Yangzhou region.Results 18 alleles of MICA have been detected in this population.The first three of most common alleles were MICA*00 8(23.0%),MICA*010(17.6%) and MICA*002/020(11.2%),and last three of rarest alleles were MICA*042(0.4%),MICA*045(1.3%)和MICA*044(1.3%).Conclusions MICA gene displayed distinct alleles distribution in Chinese south Han population. |
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| Keywords: | PCR/SSP MICA polymorphism |
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