| 利拉萘酯的合成方法改进 |
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| 引用本文： | 金荣庆,张海波,孟霆,陈言德.利拉萘酯的合成方法改进[J].中南药学,2009,7(9):676-678. |
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| 作者姓名： | 金荣庆 张海波 孟霆 陈言德 |
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| 作者单位： | 江苏(泰州)新药研究院,扬子江药业集团有限公司,江苏,泰州,225321 |
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| 摘 要： | 目的对利拉萘酯的合成方法进行改进。方法以吡啶为原料，通过光氯气化、缩合、取代、对接等反应得到利拉萘酯。结果得到了目标化舍物利拉萘酯，其熔点、红外光谱、NMR均与文献报道一致。结论此工艺稳定可行，原料易得、操作简单，适于利拉萘酯的开发与生产。
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| 关 键 词： | 利拉萘酯 抗真菌药 |
Optimization of synthesis technology for liranaftate |
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| JIN Rong-qing,ZHANG Hai-bo,MENG Ting,CHEN Yan-de.Optimization of synthesis technology for liranaftate[J].Central South Pharmacy,2009,7(9):676-678. |
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| Authors: | JIN Rong-qing ZHANG Hai-bo MENG Ting CHEN Yan-de |
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| Institution: | (Jiangsu (Taizhou) New Medicine Research Insitution , Yangtze River Pharmaceutical Group, Taizhou Jiangsu 225321) |
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| Abstract: | Objective To improve the synthesis of liranaftate. Methods The target compound was synthesized from pyridine as a raw material via steps including light reaction of chlorine, condensation, substitution and condensation. Results The structure of the target compound was confirmed by melting point, IR analysis and NMR. Conclusion This cost-saving and simplified method can be used in industrial production. |
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| Keywords: | liranaftate antifungal |
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