Opiatergic mechanisms of the cardiotropic effect of acute cooling |
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Authors: | S A Afanas'ev E D Alekseeva Yu B Lishmanov |
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Institution: | (1) Department of Experimental Cardiology, Research Institute of Cardiology, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk, USSR |
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Abstract: | Changes in myocardial contractility after an acute cold exposure following intracerebroventricular administration of opiate
receptor agonists were studied in rat hearts isolated after Langendorff. Cold exposures were carried out individually for
each animal in chambers at −10°C for 4 h. Thirty min before being exposed to cold the animals were administered in a brain
ventricle 10 μl of μ- or δ-opiate receptor agonists (DAGO or DADLE, respectively). Isolation and perfusion of the hearts were
performed directly after the cold exposure was over. The mechanism of reduction of myocardial contractility and coronary flow
induced by an acute cold exposure is believed to include stimulation of μ-opiate receptors as one of its main components,
and the effect of intracerebral hypertension on hemodynamic parameters is partially mediated through activation of δ-opiate
receptors.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 582–584, December, 1994
Presented by R. S. Karpov, Member of the Russian Academy of Medical Sciences |
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Keywords: | cold exposure isolated heart contractility |
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