| 衰老大鼠下丘脑单胺类神经递质含量的变化 |
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| 引用本文： | 陈志宏,杨国军.衰老大鼠下丘脑单胺类神经递质含量的变化[J].承德医学院学报,2005,22(2):98-99. |
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| 作者姓名： | 陈志宏 杨国军 |
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| 作者单位： | 承德医学院人体解剖学教研室,河北,承德,067000;承德医学院实验诊断学教研室 |
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| 摘 要： | 目的:观察D-半乳糖衰老大鼠下丘脑单胺类神经递质含量的变化.方法:D-半乳糖连续腹腔注射制作亚急性衰老的大鼠模型,采用高效液相色谱-电化学法检测各组大鼠下丘脑单胺类神经递质去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)的含量.结果:D-半乳糖衰老大鼠下丘脑NE、DA、5-HT的含量明显降低(与正常大鼠相比P＜0.01).结论:D-半乳糖衰老大鼠脑单胺类神经递质含量下降,这可能是D-半乳糖致衰老的作用机制之一.
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| 关 键 词： | 衰老 下丘脑 单胺类神经递质 |
| 文章编号： | 1004-6879-(2005)02-0098-02 |
| 修稿时间： | 2005年1月5日 |
STUDY ON THE CHANGES OF MONOAMINE NEUROTRANSMITTER CONTENTS IN HYPOTHALAMUS OF AGING RATS |
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| CHEN Zhi-hong,YANG Guo-jun.STUDY ON THE CHANGES OF MONOAMINE NEUROTRANSMITTER CONTENTS IN HYPOTHALAMUS OF AGING RATS[J].Journal of Chengde Medical College,2005,22(2):98-99. |
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| Authors: | CHEN Zhi-hong YANG Guo-jun |
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| Abstract: | Objective:To observe the changes of monoamine neurotransmitter contents in hypothalamus of aging rats.Methods: The sub-acutely aging rats were made by injecting D-gal into the rats' abdominal cavity continually and the monoamine transmitter contents in hypothalamus were detected with HPLC-ECD. Results:The NE, DA, 5-HT contents in hypothalamus of aging rats decreased significantly compared with normal rats (P<0.01). Conclusions: The monoamine neurotransmitter contents in brain of D-gal aging rats decreased significantly, this maybe one of the mechanisms that D-gal inducing aging. |
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| Keywords: | Aging Hypothalamus Monoamine neurotransmitter |
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