COX-2和MMP-9在胃癌组织中表达的意义及相关性

目的:探讨环氧化酶-2(COX-2)和基质金属蛋白酶-9(MMP-9)在胃癌组织中的表达及临床意义。方法:采用免疫组织化学SP法,检测65例胃癌组织和15例正常胃黏膜组织中COX-2和MMP-9的表达。结果:(1)在15例正常胃黏膜组织中COX-2和MMP-9呈阴性或弱阳性表达。在65例胃癌组织中,二者阳性表达率分别为63.08%和73.85%,明显高于正常胃黏膜组织(P<0.01)。(2)COX-2、MMP-9的表达与肿瘤细胞分化程度无关(P>0.05),与肿瘤浸润深度、TNM分期及淋巴结转移有关(P<0.05)。(3)COX-2、MMP-9在胃癌组织中的表达呈正相关(R=0.415 1,P<0.01)。结论:COX-2、MMP-9的表达在胃癌的发展过程中有重要意义,二者可能协同发挥作用。

The Significance and Correlation of COX-2 and MMP-9 Expressions in Gastric Carcinoma

Objective：To evaluate the expression of cyclooxygenase-2（COX-2）and matrix metalloproteinase-9（MMP-9）in gastric carcinoma and their prognostic significance.Methods：The detection of COX-2 and MMP-9 expression was detected in 65 cases of gastric carcinoma and 15 cases of normal gastric tissues by SP immunohistochemical technique.Results：（1）The expressions of COX-2 and MMP-9 were all weakly or strongly positive in 65 tissues of gastric carcinoma,and the strong positive rate of COX-2 and MMP-9 in gastric carcinoma was 63.08% and 73.85% respectively,while they were weakly positive or negative in all 15 cases of normal sample.（2）The expression of COX-2 and MMP-9 were highly correlated with depth of infiltration,lymph node metastasis,TNM stadium of gastric carcinoma,but not with the differentiation of gastric carcinoma cells.（3）There was a close correlation between COX-2 and MMP-9 expression in gastric carcinoma.Conclusion：COX-2 and MMP-9 expression may have great significance in the development and growth of gastric carcinoma.They may play a synergetic role in the process of gastric carcinoma carcinogenesis.