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序贯疗法与7d三联疗法治疗幽门螺杆菌的疗效比较
引用本文:马春涛,沈道明,骆成林. 序贯疗法与7d三联疗法治疗幽门螺杆菌的疗效比较[J]. 医学理论与实践, 2011, 24(22): 2663-2664
作者姓名:马春涛  沈道明  骆成林
作者单位:江苏省苏州市相城人民医院消化科,215131
摘    要:目的:比较序贯疗法与7d三联疗法治疗幽门螺杆菌的疗效。方法:92例HP阳性病例,随机分为两组:治疗组:42例前5d予质子泵抑制剂(proton pump inhibitor,PPI)和阿莫西林,后5d予PPI、克拉霉素和替硝唑。对照组:50例予PPI、阿莫西林和克拉霉素,疗程7d。结果:序贯疗法HP根除率为97.62%,7d三联疗法HP根除率为36%。结论:序贯疗法与7d三联疗法对本地区的根除率有显著差异。

关 键 词:序贯疗法  三联疗法  幽门螺杆菌  根除

Comparative Study Between Sequential Therapy and 7-day Triple Therapy in Helicobacter Pylori Infection Treatment
MA Chuntao,SHEN Daoming,LUO Chenglin. Comparative Study Between Sequential Therapy and 7-day Triple Therapy in Helicobacter Pylori Infection Treatment[J]. The Journal of Medical Theory and Practice, 2011, 24(22): 2663-2664
Authors:MA Chuntao  SHEN Daoming  LUO Chenglin
Affiliation:. Department of Gastroenterology,The Xiangcheng People's Hospital of Suzhou City,Jiangsu Province 215131
Abstract:Objective:To assess the efficacy of sequential regimen compared with conventional 7-day triple therapies.Methods:92 Helicobacter pylori(H.pylori) infected patients were enrolled.All patients were randomized either to receive 10-day sequential therapy Group(42cases),proton pump inhibitor(PPI) plus amoxicillin for the first 5 days,followed by PPI,clarithromycin and tinidazole twice daily for the remaining 5 days or to standard 7-day therapy Group(50cases),PPI,clarithromycin and amoxicillin twice daily.Results:H.pylori eradication was achieved in 41(97.62%) of 42 individuals in Sequential regimen,18(36%) of 50 in 7-day triple therapies.Conclusion:The sequential regimen is significantly more effective than 7-day triple therapies in this area.
Keywords:Sequential regimen  Triple regimen  Helicobacter pylori  Eradication
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