| 愈骨疗伤胶囊提取工艺的优化 |
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| 引用本文： | 孙艳,卞俊,许志仁,陈海飞,柳正良.愈骨疗伤胶囊提取工艺的优化[J].药学服务与研究,2011,11(5):366-369. |
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| 作者姓名： | 孙艳 卞俊 许志仁 陈海飞 柳正良 |
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| 作者单位： | 1. 解放军第411医院药学科,上海200434;江西中医学院药学院,南昌333004
2. 解放军第411医院药学科,上海,200434 |
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| 基金项目： | 重大新药创制国家科技重大专项资助项目(No.2009ZXJ09004-058) |
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| 摘 要： | 目的:建立愈骨疗伤胶囊的最佳提取工艺。方法:采用L9(33)正交试验法,用HPLC法以双波长同时测定川续断皂苷Ⅵ及柚皮苷的含量,以川续断皂苷Ⅵ及柚皮苷的转换率为评价指标,对水提、醇提和超声循环提取法进行比较。结果:醇提是最佳提取工艺,即加8倍量的55%乙醇,回流提取2次,每次1.5h。结论:该制备工艺合理、可行。
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| 关 键 词： | 愈骨疗伤胶囊 柚皮苷 川续断皂苷Ⅵ 提取工艺 正交试验 色谱法 高效液相 |
Optimization of extraction process of Yuguliaoshang capsules |
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| SUN Yan,BIAN Jun,XU ZhiRen,CHEN HaiFei,LIU ZhengLiang.Optimization of extraction process of Yuguliaoshang capsules[J].Pharmaceutical Care and Research,2011,11(5):366-369. |
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| Authors: | SUN Yan BIAN Jun XU ZhiRen CHEN HaiFei LIU ZhengLiang |
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| Institution: | SUN Yan 1,2,BIAN Jun1,XU ZhiRen1,CHEN HaiFei1,LIU ZhengLiang1(1.Department of Pharmacy,No.411 Hospital of PLA,Shanghai 200434,China,2.School of Pharmacy,Jiangxi Traditional Chinese Medicine College,Nanchang 333004,China) |
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| Abstract: | Objective： To establish an optimal extraction process of Yuguliaoshang capsules.Methods： The orthogonal test L9（33）] was used to select the optimal extraction process.The contents of asperosaponin Ⅵ and naringin were simultaneously determined by HPLC method with dual-wavelength detector.The conversion rates of asperosaponin Ⅵ and naringin were used as evaluation index.The extraction methods of water,ethanol and ultrasonic circulation were compared.Results： The optimal process was the ethanol extration.It was 1.5 h extraction with 8-fold volume of 55% ethanol for twice.Conclusion： The process is reasonable and feasible. |
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| Keywords: | Yuguliaoshang capsule naringin asperosaponin Ⅵ extraction technology orthogonal test chromatography high performance liquid |
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