Biological evaluation of novel 1,4-dithiine derivatives as potential antimicrobial agents |
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| Authors: | Anna Bielenica Jerzy Kossakowski Marta Struga Izabela Dyba?a Paolo La Colla Elena Tamburini and Roberta Loddo |
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| Institution: | (1) Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland;(2) Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031 Lublin, Poland;(3) Department of Biomedical Science and Technology, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy |
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| Abstract: | The preparation of twelve aminoalkanol derivatives of 2,3-dihydro-5H-1,4]dithiino2,3-c]pyrrole-5,7(6H)-dione was described. Newly obtained compounds, as well as their propyl and butyl analogues, were evaluated in vitro against
selected viruses. Selected derivatives were tested for their antibacterial and antifungal activity. Compounds 3h, 3j, 4b and 5a–d showed moderate to significant protections against CVB-2, HSV-1 and YFV viruses. The molecular structures of 4a, 5c and 5g were determined by an X-ray analysis. |
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