| 盐酸依匹斯汀片在中国汉族和藏族健康人体内的药动学研究 |
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| 引用本文： | 李忠亮,王晓波,张治然,袭荣刚.盐酸依匹斯汀片在中国汉族和藏族健康人体内的药动学研究[J].药学服务与研究,2011,11(5):373-376. |
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| 作者姓名： | 李忠亮 王晓波 张治然 袭荣刚 |
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| 作者单位： | 解放军第210医院药剂科,大连,116021 |
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| 摘 要： | 目的:研究汉族和藏族健康受试者单剂量口服盐酸依匹斯汀片后的药动学。方法:汉族和藏族健康受试者各10名,单剂量口服盐酸依匹斯汀片20mg,采用HPLC法测定依匹斯汀的血药浓度,DAS 2.1软件计算药动学参数,SPSS 10.0软件对不同种族、性别受试者的药动学参数进行统计分析。结果:汉族和藏族受试者的主要药动学参数为:cmax(53.21±14.23)和(51.39±17.11)ng/ml,tmax(1.88±0.36)和(1.98±0.32)h,t1/2(9.32±1.53)和(9.36±1.32)h,AUC0～60为(684.62±203.43)和(702.13±157.22)ng.h.ml-1,AUC0～∞(789.53±212.31)和(828.32±244.63)ng.h.ml-1。结论:汉族和藏族健康受试者单剂量口服盐酸依匹斯汀片20mg的体内药动学过程符合二室开放模型。药动学参数的差异无统计学意义。
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| 关 键 词： | 盐酸依匹斯汀 药代动力学 汉族 藏族 色谱法 高效液相 |
Study on pharmacokinetics of epinastine hydrochloride tablets in Chinese Han and Tibetan healthy volunteers |
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| LI ZhongLiang,WANG XiaoBo,ZHANG ZhiRan,XI RongGang.Study on pharmacokinetics of epinastine hydrochloride tablets in Chinese Han and Tibetan healthy volunteers[J].Pharmaceutical Care and Research,2011,11(5):373-376. |
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| Authors: | LI ZhongLiang WANG XiaoBo ZHANG ZhiRan XI RongGang |
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| Institution: | LI ZhongLiang,WANG XiaoBo,ZHANG ZhiRan,XI RongGang(Department of Pharmacy,the 210 Hospital of PLA,Dalian 116021) |
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| Abstract: | Objective: To investigate the pharmacokinetics of epinastine hydrochloride tablets after a single oral dose in Chinese Han and Tibetan healthy volunteers.Methods: Ten Han and ten Tibetan healthy volunteers were givien a single dose of 20 mg epinastine hydrochloride tablets orally.The plasma concentrations of epinastine were determined by HPLC method.The pharmacokinetic parameters were calculated by DAS 2.1 software and the statistical analysis of pharmacokinetic parameters of volunteers with different ethni... |
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| Keywords: | epinastine hydrochloride pharmacokinetics Han nationality Tibetan nationality chromatography high performance liquid |
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