| 探讨华法林用药规范和开展相应临床药学工作的必要性 |
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| 引用本文： | 李玥,陈敏玲,张顺国,李岚,蒋樾廉,贡沁燕.探讨华法林用药规范和开展相应临床药学工作的必要性[J].药学服务与研究,2011,11(4):254-257. |
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| 作者姓名： | 李玥 陈敏玲 张顺国 李岚 蒋樾廉 贡沁燕 |
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| 作者单位： | 1. 上海交通大学医学院附属上海儿童医学中心药剂科,上海200127;复旦大学医学院药理学系,上海200032
2. 复旦大学医学院药理学系,上海,200032 |
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| 摘 要： | 目的:提高临床医师对心脏人工机械瓣膜置换术后华法林抗凝用药规范的认识.方法:检索已有的华法林抗凝治疗循证医学文献,以此评价一名7个月先天性心脏病患儿换瓣术后,住院期间低分子量肝素、华法林和维生素K1的应用过程.结果:术后第1～4天国际标准化比值(international normalized ratio,INR)均在正常参考值范围内.术后第6天INR达抗凝目标值,静脉滴注维生素K12 mg后,INR降到正常参考值.结论:临床医师对华法林抗凝过度的误判以及应用维生素K1处置不妥,且该病例可能存在华法林抵抗现象,说明了制定华法林抗凝治疗用药规范的重要性及开展相应临床药学工作的必要性.
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| 关 键 词： | 华法林 维生素K1 心脏瓣膜 人工 临床药学 |
Discussion on standard use of warfarin and related clinical pharmacy practice |
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| LI Yue,CHEN MinLing,ZHANG ShunGuo,LI Lan,JIANG YueLian,GONG QinYan.Discussion on standard use of warfarin and related clinical pharmacy practice[J].Pharmaceutical Care and Research,2011,11(4):254-257. |
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| Authors: | LI Yue CHEN MinLing ZHANG ShunGuo LI Lan JIANG YueLian GONG QinYan |
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| Institution: | LI Yue1,CHEN MinLing1,ZHANG ShunGuo1,LI Lan1,JIANG YueLian1,GONG QinYan2(1.Department of Pharmacy,Shanghai Children's Medical Center affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China,2.Department of Pharmacology,School of Medicine,Fudan University,Shanghai 200032,China) |
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| Abstract: | Objective: To enhance the understanding of guidelines for anticoagulant therapy with warfarin after mechanical valve replacement.Methods: We retrieved the evidence-based medicine literature of anticoagulant therapy with warfarin,so as to evaluate the management of a 7-month-old patient with congenital heart disease cured by low molecular weight heparin(LMWH),warfarin and vitamin K1 after mechanical valve replacement during in hospital.Results: The international normalized ratio(INR) of the patient was in th... |
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| Keywords: | warfarin vitamin K1 heart valve prosthesis clinical pharmacy |
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