| 糖尿病人体内胰岛素抗体对胰岛素药效学的影响 |
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| 引用本文： | 黄宗之,陈辉.糖尿病人体内胰岛素抗体对胰岛素药效学的影响[J].南华大学学报(医学版),1991(2). |
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| 作者姓名： | 黄宗之 陈辉 |
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| 作者单位： | 衡阳医学院内分泌研究室，宁波市医学科学研究所 |
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| 摘 要： | 作者对10例胰岛素抗体(IAb)阴性病人和8例 IAb 阳性病人作了胰岛素药效学分析,结果表明,IAb 阳性组胰岛素累积效应和峰效应及解离常数均比 IAb 阴性组大,提示 IAb 延长了外源性胰岛素作用时间,加大胰岛素的峰作用并影响胰岛素与受体结合。
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| 关 键 词： | 胰岛素抗体 胰岛素药效动力学 |
EFFECT OF INSULIN ANTIBODY ON INSULIN PHARMACODYNAMICS IN DIABETES |
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| Huang Zongzhi Laboratory of Endocrinology,Hengyang Medical College.EFFECT OF INSULIN ANTIBODY ON INSULIN PHARMACODYNAMICS IN DIABETES[J].Journal of Nanhua University(Medical Edition),1991(2). |
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| Authors: | Huang Zongzhi Laboratory of Endocrinology Hengyang Medical College |
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| Abstract: | To investigate the effects of insulin antibody(IAb)on insulin pharmacodynamics,10 IAB-negative and 8 IAb-positive patients were monitored for 71/2 hours after subcutaneous injection of regular insulin(14U).The results show:AUCE,peak effect,and dissociation constant(K) in IAb-positive patients were larger than that in IAb-na- gative patients.These data suggest that IAb(1)prolongs the action of injected insulin;(2)increases the peak effect of insulin;(3) affects insulin binding to insulin receptor. |
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| Keywords: | Insulin Antibody Insulin Pharmacodynamics Diabetes |
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