| 心安颗粒预处理对大鼠心肌缺血再灌注心律失常和心肌MDA、SOD的影响 |
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| 引用本文： | 刘大勇,刘奇,杨思进,白雪,陈美娟,江云东. 心安颗粒预处理对大鼠心肌缺血再灌注心律失常和心肌MDA、SOD的影响[J]. 川北医学院学报, 2008, 23(5) |
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| 作者姓名： | 刘大勇 刘奇 杨思进 白雪 陈美娟 江云东 |
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| 作者单位： | 泸州市120急救指挥中心,四川,泸州,646000;泸州医学院附属中医医院心脑内科,四川,泸州,646000;泸州医学院药学院,四川,泸州,646000 |
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| 摘 要： | 目的探讨心安颗粒预处理对心肌缺血再灌注心律失常和心肌MDA、SOD的影响。方法健康雄性SD大鼠60只,随机分为6组,每组10只。结扎大鼠左冠状动脉建立大鼠心肌缺血再灌注损伤模型,记录Ⅱ导联心电图,并测定心肌组织中丙二醛(MDA)和超氧化物歧化酶(SOD)含量。结果心安颗粒可以明显减少大鼠缺血再灌注心律失常VP(p<0.05)、VT(p<0.05或p<0.01)、VF(p<0.01)及AVB(p<0.05或p<0.01)的发生。明显升高心肌SOD的含量(p<0.01),明显降低MDA含量(p<0.01)。结论心安颗粒可能是通过抑制由心肌缺血再灌注损伤引起的MDA生成,提高心肌组织SOD的活力实现抗心律失常作用。
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| 关 键 词： | 预处理 心肌缺血再灌注 心律失常 MDA SOD |
Effect of Xinan Granule on Arrhythmia and Cardiac Muscle MDA and SOD in Rats with Myocardial Ischemia/Reperfusion Injury |
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| LIU Da-yong,LIU Qi,YANG Si-jin,BAI Xue,CHENG Mei-juan,JIANG Yun-dong. Effect of Xinan Granule on Arrhythmia and Cardiac Muscle MDA and SOD in Rats with Myocardial Ischemia/Reperfusion Injury[J]. Journal of North Sichuan Medical College, 2008, 23(5) |
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| Authors: | LIU Da-yong LIU Qi YANG Si-jin BAI Xue CHENG Mei-juan JIANG Yun-dong |
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| Affiliation: | 1.Luzhou 120 First Aid Control Center;2.Department of Cardiology;The Second Affiliated Hospital of Luzhou Medical College;3.Department of Pharmacology;Luzhou Medical College;Luzhou;Sichuan 646000;China |
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| Abstract: | Objective The authors discussed the effect of Xinan Granule on arrhythmia and cardiac muscle MDA and SOD in rats with myocardial ischemia/reperfusion injury.Methods 60 male SD rats were divided into 6 groups at random,10 in each group.Left coronary artery was tied up to establish the damage model of cardiac muscle ischemia,then electrocardiogram was obtained and the SOD content and MDA in the cardiac muscle was detected.Results Xinan Granule can significantly reduce the rat ischemic reperfusion arrhythmia V... |
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| Keywords: | MDA SOD |
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