Photo-damage protective effect of two facial products, containing a unique complex of Dead Sea minerals and Himalayan actives |
| |
Authors: | Eitan Wineman Meital Portugal-Cohen Yoram Soroka Dror Cohen Gerrit Schlippe Werner Voss Sarah Brenner Yoram Milner Noam Hai Zeevi Ma'or |
| |
Institution: | 1. The Dead Sea Laboratory for Skin Biochemistry and Biotechnology, The Dead Sea and Arava Science Center, Ein‐Gedi, Israel;2. AHAVA – Dead Sea Laboratories, Airport City, Israel;3. Department of Biological Chemistry, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel;4. Dermatest? Medical Research Company, Muenster, Germany;5. The Institute for Skin Research, Tel‐Aviv, Israel;6. Atidim, Medicla Center, Tel‐Aviv, Israel |
| |
Abstract: | Background Skin appearance is badly affected when exposed to solar UV rays, which encourage physiological and structural cutaneous alterations that eventually lead to skin photo-damage. Aims To test the capability of two facial preparations, extreme day cream (EXD) and extreme night treatment (EXN), containing a unique complex of Dead Sea water and three Himalayan extracts, to antagonize biological effects induced by photo-damage. Methods Pieces of organ cultures of human skin were used as a model to assess the biological effects of UVB irradiation and the protective effect of topical application of two Extreme preparations. Skin pieces were analyzed for mitochondrial activity by MTT assay, for apoptosis by caspase 3 assay, and for cytokine secretion by solid phase ELISA. Human subjects were tested to evaluate the effect of Extreme preparations on skin wrinkle depth using PRIMOS and skin hydration by a corneometer. Results UVB irradiation induced cell apoptosis in the epidermis of skin organ cultures and increased their pro-inflammatory cytokine, tumor necrosis α (TNFα) secretion. Topical applications of both preparations significantly attenuated all these effects. Furthermore, in human subjects, a reduction in wrinkle depth and an elevation in the intense skin moisture were observed. Conclusions The observations clearly show that EXD and EXN preparations have protective anti-apoptotic and anti-inflammatory properties that can attenuate biological effects of skin photo-damage. Topical application of the preparations improves skin appearance by reducing its wrinkles depth and increasing its moisturizing impact. |
| |
Keywords: | photo‐damage apoptosis inflammation reactive oxygen species (ROS) Dead Sea minerals Himalayan extracts |
本文献已被 PubMed 等数据库收录! |
|