Association between adult height, genetic susceptibility and risk of glioma |
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| Authors: | Cari M Kitahara Sophia S Wang Beatrice S Melin Zhaoming Wang Melissa Braganza Peter D Inskip Demetrius Albanes Ulrika Andersson Laura E Beane Freeman Julie E Buring Tania Carreón Maria Feychting Susan M Gapstur J Michael Gaziano Graham G Giles Goran Hallmans Susan E Hankinson Roger Henriksson Ann W Hsing Christoffer Johansen Martha S Linet Roberta McKean-Cowdin Dominique S Michaud Ulrike Peters Mark P Purdue Nathaniel Rothman Avima M Ruder Howard D Sesso Gianluca Severi Xiao-Ou Shu Victoria L Stevens Kala Visvanathan Martha A Waters Emily White Alicja Wolk Anne Zeleniuch-Jacquotte Wei Zheng |
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| Institution: | Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA, Division of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, CA, USA, Department of Radiation Sciences, Oncology, Ume? University, Ume?, Sweden, Core Genotyping Facility, National Cancer Institute, SAIC-Frederick, Inc., Gaithersburg, MD, USA, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Massachusetts Veterans Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, VA Boston Healthcare System, Boston, MA, USA, Cancer Epidemiology Centre, The Cancer Council of Victoria, Melbourne, Australia, Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia, Department of Public Health and Clinical Medicine/Nutritional Research, Ume? University, Ume?, Sweden, Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Department of Oncology, Karolinska University Hospital, Stockholm, Sweden, Unit of Survivorship, Danish Cancer Society, Copenhagen, Denmark, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, Department of Epidemiology, Brown University, Providence, RI, USA, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, Department of Epidemiology, University of Washington, Seattle, WA, USA, Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA and Division of Epidemiology, Department of Environmental Medicine, NYU School of Medicine, New York, NY, USA. |
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| Abstract: | BACKGROUND: Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease. METHODS: We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants. RESULTS: Among men, we found a positive association between height and glioma risk (≥190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (≥175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk. CONCLUSION: An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease. |
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