Role of protein kinase C in the regulation of acetylcholine release in the central nervous system of spontaneously hypertensive rats |
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Authors: | Tsuda Kazushi Tsuda Seiko Nishio Ichiro |
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Affiliation: | Division of Cardiology, Wakayama Medical University, Wakayama, Japan. tsudak@mail.wakayama-med.ac.jp |
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Abstract: | Previous studies have shown that the central cholinergic nervous system may be involved in blood pressure control. In the present study, we investigated the role of protein kinase C in the regulation of cholinergic nervous activity in the central nervous system in hypertension. In superfused slices of the striatum obtained from spontaneously hypertensive rats and age-matched Wistar-Kyoto rats, we examined the effects of the protein kinase C inhibitor H-7 on the release of [3H]-acetylcholine in vitro. The stimulation-evoked [3H]-acetylcholine release was not different between spontaneously hypertensive rats and Wistar-Kyoto rats. The protein kinase C inhibitor H-7 reduced the stimulation-evoked [3H]-acetylcholine release to a greater extent in spontaneously hypertensive rats than in Wistar-Kyoto rats. The results of the present study showed that the enhanced calcium-protein kinase C system might actively participate in the regulation of cholinergic nervous activity in the central nervous system in hypertension. |
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