H型血管铁死亡对骨质疏松性骨关节炎的影响及调节机制研究

随着全社会人口老龄化的加剧,绝经后女性罹患骨质疏松性骨关节炎的风险亦呈现高发趋势,严重危害中老年人的健康。研究证实血管形成及功能异常是加剧骨质疏松、骨关节炎病理退变的重要事件。H型血管(内皮细胞)在骨与软骨损伤修复中兼具成骨和成血管偶联功能,其形态与功能异常将影响骨质疏松、骨关节炎的损伤修复。铁死亡作为近年来发现的一种新型细胞死亡模式,其主要由铁依赖性脂质过氧化和活性氧诱导损伤引起细胞膜断裂,线粒体变小等改变。而H型血管铁死亡对骨质疏松性骨关节炎病程的影响途径及调节机制尚需进一步探讨,旨在为今后以H型血管铁死亡为切入点进而防治骨质疏松性骨关节炎开辟新方向。

The effect and regulatory mechanism of the ferroptosis in type H vessels on osteoporotic osteoarthritis

The risk of osteoporotic osteoarthritis increases with age in postmenopausal women, which seriously endangers the life and health of the elderly. Modern research has found that vascular formation and abnormal function are important events that aggravate the pathological degeneration of osteoporosis and osteoarthritis. However, the function of type H vessels coupling for angiogenesis and osteogenesis is beneficial to the repair of osteoporosis and osteoarthritis. Ferroptosis, as a new cell death pattern, has been discovered in recent years which is mainly caused by iron-dependent lipid peroxidation and damage induced by reactive oxygen species. However, the way and mechanism of the effect of ferroptosis of type H vessels on the course of osteoporotic osteoarthritis is to be explored. This paper aims to open up a new direction for the prevention and treatment of osteoporotic osteoarthritis by taking the ferroptosis of type H vessels as the entry point in the future.