| 对乙醇挥发性杂质方法的探讨及优化 |
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| 引用本文： | 胡淑君,陈英. 对乙醇挥发性杂质方法的探讨及优化[J]. 中国药品标准, 2021, 22(2): 155-158 |
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| 作者姓名： | 胡淑君 陈英 |
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| 作者单位： | 广东省药品检验所 |
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| 基金项目： | 国家药典委员会标准提高课题(编号ZG2017-5-03)。 |
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| 摘 要： | 目的:探讨并尝试优化乙醇挥发性杂质的检测方法.方法:采用Supelco OVI-G43色谱柱(30 m×0.53 mm,3.0μm);起始柱温:40℃,以每分钟10℃的速率升温至240℃,维持10 min;进样口温度200℃;检测器温度280℃.结果:甲醇、乙醛和乙缩醛、苯的平均回收率分别为91.2％、104.9％、9...
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| 关 键 词： | 乙醇 挥发性杂质 检测方法 优化 |
Discussion and optimization on the test method of volatile impurities in ethanol |
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| HU Shujun,CHEN Ying. Discussion and optimization on the test method of volatile impurities in ethanol[J]. , 2021, 22(2): 155-158 |
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| Authors: | HU Shujun CHEN Ying |
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| Affiliation: | (Guangdong Institute for Drug Control,Guangzhou 510663,China) |
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| Abstract: | Objective:To discuss and optimize the test method of volatile impurities in ethanol.Methods:The separation was performed in a Supelco OVI-G43 GC column(30 m×0.53 mm,3.0μm)under the programmed temperature procedure.The programmed procedure was as follow:initial column temperature at 40℃,increasing to 240℃at 10℃per min,and maintaining 240℃for 10 min.The injection temperature was 200℃,and the detection temperature was 280℃.Results:The average recoveries of methanol,acetaldehyde and acetal,and benzene were 91.2%,104.9%,96.0%with RSD as 2.3%,3.0%,6.3%,respectively.Conclusion:The established method has the good precision,repeatability and accuracy.It can meet the requirements of the volatile impurities in ethanol. |
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| Keywords: | ethanol volatile impurities testing method optimization |
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