Potential cardiotonic agents. 6. Synthesis and cardiovascular properties of 5-(4-pyridinyl)-, 6-methyl-5-(4-pyridinyl)- and 6-methyl-5-phenyl-substituted 3-cyano-2-oxaalkyoxy-pyridines |
| |
Authors: | V Hagen E Klauschenz A Rumler A Hagen S Heer R Mitzner H Niedrich D Lohmann |
| |
Institution: | Akademie, Wissenschaften, DDR. |
| |
Abstract: | The headline compounds were prepared by the reaction of 2-chloropyridines 1-3 with the appropriate alcohols in presence of potassium hydroxide and the sodium alkoxides, respectively. Especially some of the 3-cyano-2-hydroxyalkoxy-5-(4-pyridinyl)pyridines showed remarkable positive inotropic potency and, additionally, a vasodilator activity. In spontaneously beating isolated guinea pig atria they had a greater activity than amrinone. |
| |
Keywords: | |
|
|