Preliminary Phase II Study of 1-(2-Chloroethyl)-3-(MethylAlpha-D-Glucopyranos-6-Yl)-1-Nitrosourea (MCNU) Against Primary Lung Cancer and Metastatic Pulmonary Tumors |
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Authors: | SHIMABUKURO, ZENTETSU SAIJO, NAGAHIRO TOMINAGA, KEIGO SHINKAI, TETSU EGUCHI, KENJI SHIMIZU, EIJI SHIBUYA, MASAHIKO HOSHI, AKIO |
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Affiliation: | Department of Internal Medicine, National Cancer Center Hospital Tokyo *Pharmacology Division, National Cancer Center Research Institute Tokyo |
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Abstract: | A phase II study of 1-(2-chloroethyl)-3-(methyl--D-glucopyranos-6-yl)-1-nitrosourea(MCNU) was conducted with 16 patients with primary lung canceror metastatic pulmonary tumors who had failed to respond toconventional therapy. MCNU was administered by a single intravenousinjection at a dose of 120 mg/m2. There were no patients whoshowed any objective responses. Although stabilization was achievedin 12 patients, four patients with primary lung cancer experiencedprogressive disease. Gastrointestinal toxicities such as anorexia,nausea and vomiting were mild or moderate and readily subsidedwithout any treatment. The major toxic side effects were leukocytopeniaand thrombocytopenia. Five patients (38.4%) had leukocytopeniaof less than 2,000/mm3 and six patients (46.1%) had thrombocytopeniaof less than 5.0x104/mm3. |
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