加味参附颗粒治疗充血性心力衰竭及对甲状腺激素的影响

目的 观察加味参附颗粒治疗充血性心力衰竭(CHF)的疗效及对甲状腺激素的影响。方法 将62例患者随机分为两组,对照组以西医常规治疗,治疗组在西医常规治疗的基础上加服加味参附颗粒,疗程均为2周。治疗前后采用放射免疫法检测三碘甲状腺原氨酸(T3)、甲状腺素(T4)、反三碘甲状腺原氨酸(rT3)及促甲状腺激素(TSH)。结果 治疗组总有效率显著优于对照组,平均疗程显著低于对照组;经2周治疗后,治疗组和对照组的T3由治疗前较低水平显著升高,rT3由治疗前的较高水平显著降低(P<0.05,P<0.01),而治疗组治疗后这2项指标与对照组比较有显著性差异(P<0.05,P<0.01)。结论 加味参附颗粒治疗CHF不仅可提高疗效、缩短疗程,而且可显著纠正CHF患者异常的甲状腺激素。

Effect of Increased Ingredient's Ginseng Mankshood Granule in Treating Congestive Heart Failure and Its Influence on Thyroid Hormones

Objective To observe the effect of increased ingredient's Ginseng Mankshood Granule on congestive heart failure (CHF) and its influence on thyroid hormones. Methods Sixty-two Patients of CHF were divided into two groups. On the basis of conventional treatment of western medicine, the increased ingredient's Ginseng Mankshood Granule was given to the treated group additionally. Blood level of triiodothyronine (T3), thyroxine (T4), reverse triiodothyronine (rT3) and thyroid stimulating hormone (TSH) of all patients were determined before and after treatment by radioimmunoassay. Results There were significant difference between the treated group and the control group in cure rate and mean course of therapy. The levels of T3 of all patients were lower than those of the normal control before treatment, and rT3 were higher. Two weeks after treatment, T3 level in all patients increased significantly and rT3 level significantly decreased (P<0.05, P<0.01). Conclusion Increased ingredient's Ginseng Mankshood Granule has a good effect on patients with CHF. It also has regulatory effect on thyroid hormones.