| 壮尔颗粒对小鼠细胞免疫功能的影响 |
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| 引用本文： | 宋铁玎,李红,王雪峰,张君,程嘉艺.壮尔颗粒对小鼠细胞免疫功能的影响[J].中药新药与临床药理,2006,17(3):177-179. |
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| 作者姓名： | 宋铁玎 李红 王雪峰 张君 程嘉艺 |
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| 作者单位： | 1. 辽宁中医药大学附属医院,沈阳,110032
2. 辽宁中医药大学,沈阳,110032 |
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| 基金项目： | 辽宁省沈阳市科技局重点项目“中药壮尔颗粒治疗反复呼吸道感染的新药研究”(1032041-1-04) |
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| 摘 要： | 目的观察壮尔颗粒(Zhuang'erGranules,ZG)对小鼠细胞免疫功能的影响。方法用氢化可的松建立免疫抑制小鼠模型,灌胃7d后,采用体外法测定小鼠巨噬细胞吞噬功能,形态学检测法测定小鼠淋巴细胞转化率。结果与对照组相比较,ZG对正常小鼠和免疫抑制小鼠均具有显著增强巨噬细胞吞噬功能和提高淋巴细胞转化百分率的作用(P<0.05),且作用呈量效关系。结论ZG具有一定的提高小鼠细胞免疫功能的作用。
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| 关 键 词： | 壮尔颗粒 细胞免疫 巨噬细胞吞噬功能 淋巴细胞转化率 |
| 文章编号： | 1003-9783（2006）03-0177-03 |
| 收稿时间： | 2005-12-11 |
| 修稿时间： | 2005年12月11 |
Effect of Zhuang 'er Granules on Cellular Immune Function of Mice |
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| SONG Tieding,LI Hong,WANG Xuefeng,ZHANG Jun,CHENG Jiayi.Effect of Zhuang ''''er Granules on Cellular Immune Function of Mice[J].Traditional Chinese Drug Research & Clinical Pharmacology,2006,17(3):177-179. |
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| Authors: | SONG Tieding LI Hong WANG Xuefeng ZHANG Jun CHENG Jiayi |
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| Institution: | 1. The Affiliated Hospital of Liaoning University of TCM, Shenyang 110032; 2. Liaoning University of TCM, Shenyang 110032 |
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| Abstract: | Objective To study the effect of Zhuang'er Granules(ZG) on cellular immune function of mice.Methods The immunodepression mice models were induced by injection of hydrocortisone.Then the lymphocyte transformation rate was examined by morphological test and phagocyte phagocytosis by in vitro method after 7-day intragastric administration of the drugs.Results Compared with the negative control group,ZG could significantly improve the lymphocyte transformation rate and phagocyte phagocytosis in the normal mice and immunodepression mice(P < 0.05) in a dose-effect manner.Conclusion ZG has a certain effect in advancing cellular immune function of mice. |
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| Keywords: | Zhuang'er Granules Cellular immunity Phagocyte phagocytosis Lymphocyte conversion ratio |
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