Immune Mechanisms and the Action of Interferon in Chronic Hepatitis B Virus Infection |
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Authors: | Adrian O. Vladutiu |
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Affiliation: | a Department of Pathology, SUNY at Buffalo, School of Medicine and Laboratory of Immunopathology, The Buffalo General Hospital, Buffalo, NY |
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Abstract: | Cytotoxic T lymphocytes can eliminate cells infected with hepatitis B virus. A defect of T lymphocyte-mediated cytolysis seems to exist in chronic hepatitis B infection. T cell-mediated lysis is dependent on HLA antigens of the infected host and this may explain the increased or decreased frequency of particular HLA antigens in chronic carriers of hepatitis B virus. This virus may decrease the concentration of HLA antigens expressed on liver cells. Interferon increases the HLA antigen expression on T lymphocytes and hepatocytes, thereby enhancing T lymphocyte-mediated lysis of infected liver cells and elimination of the hepatitis B virus. |
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