围生期孕妇阴道分泌物细菌培养及耐药性分析

目的了解围生期孕妇阴道病原菌分布及其药敏情况。方法对10 800例妇女(围生期孕妇和非妊娠期妇女各5 400例)阴道分泌物标本进行细菌培养及药敏试验。结果5 400例围生期孕妇病原菌检出率为26.00%(1 404株),其中真菌759株,革兰阳性球菌611株,革兰阴性杆菌32株,淋病奈瑟菌2株;5 400例非妊娠妇女病原菌检出率为7.87%(425株),其中真菌232株,革兰阳性球菌182株,革兰阴性杆菌5株,淋病奈瑟菌6株。围生期孕妇分离的无乳链球菌对红霉素、克林霉素耐药率为84.85%和80.81%,金黄色葡萄球菌对红霉素耐药率为40.91%,大肠埃希菌对四环素、复方磺胺甲口恶唑耐药率为69.23%和53.85%,淋病奈瑟菌对青霉素、复方磺胺甲口恶唑耐药率100.00%。结论围生期孕妇阴道较非妊娠育龄妇女病原菌感染率更高,加强围生期孕妇阴道病原菌的筛查力度,对保障母婴安全具有重要的临床意义。

Bacterial culture and drug resistance of vaginal discharge in perinatal pregnant women

ObjectiveTo investigate the distribution and drug susceptibility of vaginal pathogens in pregnant women during perinatal period.MethodsVaginal discharge specimens of 10 800 women (5 400 were pregnant women during perinatal period, 5 400 were non pregnant women) were performed bacterial culture and drug susceptibility testing. ResultsThe isolation rate of pathogens from 5 400 perinatal pregnant women was 26.00% (n=1 404), including 759 strains of fungi, 611 strains of gram positive cocci, 32 strains of gram negative bacilli, 2 strains of Neisseria gonorrhoeae; among 5 400 non pregnant women, the isolation rate of pathogens was 7.87% (n=425), including 232 strains of fungi, 182 strains of gram positive cocci, 5 strains of gram negative bacilli, and 6 strains of Neisseria gonorrhoeae. Resistance rates of Streptococcus agalactiae isolated from perinatal pregnant women to erythromycin and clindamycin were 84.85% and 80.81% respectively，resistance rate of Staphylococcus aureus to erythromycin was 40.91%, resistance rates of Escherichia coli to tetracycline and sulfamethoxazole/trimethoprim were 69.23% and 53.85% respectively, resistance rate of Neisseria gonorrhoeae to penicillin and sulfamethoxazole/trimethoprim was 100.00%. ConclusionVaginal infection rate in perinatal pregnant women is higher than non pregnant women, screening of vaginal pathogens in perinatal pregnant women should be strengthened, so as to ensure the safety of mothers and infants.