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长期吸烟者血浆皮质醇及β-内啡肽的变化
引用本文:傅丽媛,杜同信,余红勇,王自正,陈宗华. 长期吸烟者血浆皮质醇及β-内啡肽的变化[J]. 中国药物依赖性杂志, 2002, 11(1): 31-32
作者姓名:傅丽媛  杜同信  余红勇  王自正  陈宗华
作者单位:1. 南京中医药大学,南京,210029
2. 南京医科大学南京第一医院放免中心,南京,210006
摘    要:目的·· :探讨长期吸烟者在戒烟前后血浆皮质醇和 β-内啡肽水平的变化及形成机制。方法·· :于戒烟前后采集长期吸烟者静脉血 ,用放射免疫方法检测血浆皮质醇及血浆 β-内啡肽的含量。结果·· :长期吸烟者的血浆皮质醇(227.82ng·ml-1±s40.03ng·ml-1)及血浆 β-内啡肽(14.68ng·ml-1±s4.48ng·ml-1)明显高于正常组 ;戒断后长期吸烟组的血浆皮质醇(271.92ng·ml-1±s32.19ng·ml-1)明显升高 ,而血浆 β-内啡肽(8.16ng·ml-1±s4.97ng·ml-1)明显降低。结论·· :血浆皮质醇及 β-内啡肽可作为判断戒烟治疗效果的指标之一 ,而改善内源性阿片肽系统及下丘脑 -垂体 -肾上腺轴的功能可能对戒烟有助。

关 键 词:烟草成瘾  血浆皮质醇  血浆β-内啡肽
修稿时间:2001-03-19

CHANGES OF CORTISOL AND β - ENDORPHIN IN CHRONIC SMOKERS
FU Liyuan,DU Tongxin,YU Hongyong,WANG Zizheng,CHEN Zonghua. CHANGES OF CORTISOL AND β - ENDORPHIN IN CHRONIC SMOKERS[J]. Chinese Journal of Drug Dependence, 2002, 11(1): 31-32
Authors:FU Liyuan  DU Tongxin  YU Hongyong  WANG Zizheng  CHEN Zonghua
Affiliation:FU Liyuan1,DU Tongxin2,YU Hongyong1,WANG Zizheng2,CHEN Zonghua21
Abstract:Objective: To observe the changes of cortisol and β-endorphin contents of chronic smokers. Methods: Blood samples of 40 smokers were taken at the smoking stage and natural withdrawal stage to check the content of cortisol and β-endorphin in plasm with radioimmunoassay and compared with those of 25 non-smokers. Results: The contents of cortisol and β-endorphin of smokers were obviously higher than those of non-smokers. After smoking abstinence, the level of cortisol increased while the content of β-endorphin decreased. Conclusion: The contents of cortisol and β-endorphin in plasma can be one of the index to measure the effect of smoking abstinence. Improving the function of endogenous opioid peptides system and hypothalamus-pituitary-adrenal axis may be of help for smoking abstinence.
Keywords:tobacco addiction   β-endorphin   cortisol
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