| 长期吸烟者血浆皮质醇及β-内啡肽的变化 |
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| 引用本文： | 傅丽媛,杜同信,余红勇,王自正,陈宗华.长期吸烟者血浆皮质醇及β-内啡肽的变化[J].中国药物依赖性杂志,2002,11(1):31-32. |
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| 作者姓名： | 傅丽媛 杜同信 余红勇 王自正 陈宗华 |
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| 作者单位： | 1. 南京中医药大学,南京,210029
2. 南京医科大学南京第一医院放免中心,南京,210006 |
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| 摘 要： | 目的·· :探讨长期吸烟者在戒烟前后血浆皮质醇和 β-内啡肽水平的变化及形成机制。方法·· :于戒烟前后采集长期吸烟者静脉血 ,用放射免疫方法检测血浆皮质醇及血浆 β-内啡肽的含量。结果·· :长期吸烟者的血浆皮质醇(227.82ng·ml-1±s40.03ng·ml-1)及血浆 β-内啡肽(14.68ng·ml-1±s4.48ng·ml-1)明显高于正常组 ;戒断后长期吸烟组的血浆皮质醇(271.92ng·ml-1±s32.19ng·ml-1)明显升高 ,而血浆 β-内啡肽(8.16ng·ml-1±s4.97ng·ml-1)明显降低。结论·· :血浆皮质醇及 β-内啡肽可作为判断戒烟治疗效果的指标之一 ,而改善内源性阿片肽系统及下丘脑 -垂体 -肾上腺轴的功能可能对戒烟有助。
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| 关 键 词： | 烟草成瘾 血浆皮质醇 血浆β-内啡肽 |
| 修稿时间： | 2001年3月19日 |
CHANGES OF CORTISOL AND β - ENDORPHIN IN CHRONIC SMOKERS |
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| FU Liyuan,DU Tongxin,YU Hongyong,WANG Zizheng,CHEN Zonghua.CHANGES OF CORTISOL AND β - ENDORPHIN IN CHRONIC SMOKERS[J].Chinese Journal of Drug Dependence,2002,11(1):31-32. |
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| Authors: | FU Liyuan DU Tongxin YU Hongyong WANG Zizheng CHEN Zonghua |
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| Institution: | FU Liyuan1,DU Tongxin2,YU Hongyong1,WANG Zizheng2,CHEN Zonghua21 |
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| Abstract: | Objective: To observe the changes of cortisol and β-endorphin contents of chronic smokers. Methods: Blood samples of 40 smokers were taken at the smoking stage and natural withdrawal stage to check the content of cortisol and β-endorphin in plasm with radioimmunoassay and compared with those of 25 non-smokers. Results: The contents of cortisol and β-endorphin of smokers were obviously higher than those of non-smokers. After smoking abstinence, the level of cortisol increased while the content of β-endorphin decreased. Conclusion: The contents of cortisol and β-endorphin in plasma can be one of the index to measure the effect of smoking abstinence. Improving the function of endogenous opioid peptides system and hypothalamus-pituitary-adrenal axis may be of help for smoking abstinence. |
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| Keywords: | tobacco addiction β-endorphin cortisol |
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