血清总胆汁酸和前白蛋白联合检测在肺结核病中的临床意义

目的探讨血清总胆汁酸（TBA）和前白蛋白（PA）联合检测在肺结核病中的临床应用价值。方法采用循环酶法和免疫透射比浊法分别检测406例肺结核病人治疗前后血清TBA和PA，同时检测丙氨酸氨基转移酶（ALT）及天门冬氨酸氨基转移酶（AST）作为对比。结果在肺结核病人治疗1个月后血清TBA和PA检测结果较治疗前结果差异有最著性意义（P〈0．01），ALT和AST均较治疗前升高（P〈0．05）；随着疗程的延长，血清PA显著降低（P〈0．01）．而TBA显著升高（P〈0．01）：治疗后1个月血清PA和TBA的异常率分别为89．9％和56％，与ALT和AST的异常率相比较有显著性差异（P〈0．01）．治疗3个月后，血清ALT和AST的异常率（98％、99％）和TBA的异常率（83％）的差异有显著性意义（P〈0．05）。结论联合检测血清TBA和PA对判断抗结核治疗后早期肝功能损伤有重要临床意义，可作为抗结核治疗后检测肝功能的常规指标。

The clinical significance of co-detections of serum prealbumin and total bile acid in pulmonary tuberculosis

Objective To investigate the clinical significance of co-detections of serum total bile acid(TBA)and prealbumin (PA)in pulmonary tuberculosis. Methods Serum TBA and PA in 406 patients with pulmonary tuberculosis before and after therapy were detected byim- munoturbidimetry and circulating enzyme,at the same time,ALT and AST were detected as con- trol. Results Serum TBA and PA of these patients between before the therapy and onemonth afterthe the rapy were significant difference (P< 0.01), the levels of ALT and AST were higher than those of before the therapy(P< 0.05),following up the courseb of treatment,PA decreased and TBA increased statistically significant (P< 0.01). One month after the therapy the positive rate of PA and TBA were89.9% and 56% respectively, comparing with thoseofALT and AST were significant difference(P< 0.01),three months after the therapy the positive rate of ALT and AST werehigherthanthatofTBA(P< 0.05).Conclusions Co-detections of PA and TBA have an important valuein predict ingtheearly damage of liver function after anti-tuberculosis treatment, it can be used as an routine liver function indexes of patients with the treatment of pulmonary tuberculosis.