Serial serum SARS-CoV-2 RNA results in two COVID-19 cases with severe respiratory failure |
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| Affiliation: | 1. Division of Pulmonary Medicine, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan;2. Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan;3. Department of Anesthesiology, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan;4. Department of Emergency, Japan Self Defense Force Sapporo Hospital, 17 Makomanai, Minami, Sapporo 005-8543, Japan;5. Department of Internal Medicine, Japan Self Defense Forces Hospital, 1776-1 Tauraminatomachi, Yokosuka, Kanagawa 237-0071, Japan;6. Division of Infectious Disease, Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo 154-8532, Japan |
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| Abstract: | Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment.To examine the course of infection, we performed reverse-transcription (RT) polymerase chain reaction assay with serum specimens, and serum SARS-CoV-2 RNA was detected in both cases when body temperature increased and respiratory status deteriorated. We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course. |
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| Keywords: | COVID-19 Severe respiratory failure Serum SARS-CoV-2 RNA |
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