Relationship between cytopenia and gestational age in infants and neonates treated with linezolid therapy |
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| Affiliation: | 1. Department of Infection Control and Prevention, Aichi Medical University Hospital, Japan;2. Department of Pharmacy, Aichi Medical University Hospital, Japan;3. Division of Hematology, Department of Internal Medicine, Aichi Medical University Hospital, Japan;1. Department of General Internal Medicine, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan;2. Department of Microbiology and Infectious Diseases, Toho University School of Medicine, Tokyo, Japan;3. Department of Clinical Laboratory, National Hospital Organization, Tokyo Medical Center, Tokyo, Japan;1. Department of Infection Prevention and Control, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan;2. Department of Microbiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan;3. Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan;4. Division of General Medicine, Tachikawa Sogo Hospital, 4-1 Midori-Cho, Tachikawa, Tokyo 190-8578, Japan;5. Department of Infection Prevention and Control, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo 193-0998, Japan;6. Department of Medicine, International University of Health and Welfare, 4-3 Kozunomori, Narita City, Chiba Prefecture, 286-8686, Japan;1. Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan;2. Department of Infectious Diseases, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo 187-8510, Japan;3. Department of Emergency Medicine, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo 187-8510, Japan;1. Department of Infectious Disease and Infection Control, Saitama Medical University, Saitama, Japan;2. Center for Clinical Infectious Diseases and Research, Saitama Medical University, Saitama, Japan;3. Department of Internal Medicine, Akiru Municipal Medical Center, Tokyo, Japan;4. Department of Ophthalmology, Saitama Medical University, Saitama, Japan;5. Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan;1. Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University School of Medicine, Japan;2. Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University Kashiwa Hospital, Japan;3. Division of Human Pathology and Morphology, The Jikei University School of Medicine, Japan |
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| Abstract: | BackgroundLinezolid has been the common antimicrobial treatment for Gram-positive infection even in neonates and infants. Major adverse events associated with linezolid treatment is cytopenia. However, there were few reports about the relationship between cytopenia and gestational age. Primary objective of this study was to compare the relationship between cytopenia in infants and neonates treated with linezolid therapy and gestational age.MethodsIn total, 44 patients were divided into two groups depend on their gestational age [<180 days; low gestational age group (20 patients); >180 days group; high gestational age group (24 patients)]. All patients treated with linezolid from April 2014 to March 2018 at NICU or GCU of Aichi Medical University Hospital. Investigation items were as follows; sex, age, weight, duration of treatment, Apgar score, laboratory data, rate of patients with blood transfusion, concomitant medications, hematologic abnormalities during linezolid treatment.ResultsThe incidence of overall cytopenia in low gestational age group was significantly higher than high gestational age group (65.0 % vs. 25.0 %; p < 0.05). Of note, the incidence of thrombocytopenia in low gestational age group showed significantly higher than high gestational age group (45.0% vs. 8.3%, p < 0.05). Then, the proportion of patients occurred thrombocytopenia who received linezolid 10 mg/kg every 8 h were higher than 10 mg/kg every 12 h in both groups.ConclusionIn cases linezolid is administered three times a day should be more carefully of thrombocytopenia in patients with gestational days less than 180 days. |
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| Keywords: | Linezolid Cytopenia Thrombocytopenia Neonates Gestational age |
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