Outcome of radiotherapy for invasive bladder cancer in older patients – not candidates for or decline cystectomy |
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| Institution: | 1. Department of Radiotherapy, Centro Hospitalar Universitário de São João, Alameda Prof. Hernâni Monteiro, 4200–319 Porto, Portugal;2. Departamento de Estudo de Populações, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal;3. CINTESIS, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Rua de Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal;4. EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, No. 135, 4050-600 Porto, Portugal;1. Department of Radiation Oncology, Gustave-Roussy, Paris-Saclay University, Villejuif, France;2. Department of Gynecologic Surgery, Gustave-Roussy, Villejuif, France;3. Department of Pathology, Gustave-Roussy, Villejuif, France;4. Department of Medical Oncology, Gustave-Roussy, Villejuif, France;5. GIE Charlebourg, groupe Amethyst, 65, avenue Foch, 92250 La-Garenne-Colombes, France;6. French Military Health Academy, Paris, France;7. Institut de recherche biomédicale des armées, Brétigny-sur-Orge, France;1. Department of radiotherapy, CHU de Besancon, 2, boulevard Fleming, 25030 Besançon, France;2. Department of radiotherapy, Gustave-Roussy Cancer Campus, 114, rue Édouard-Vaillant, 94805 Villejuif, France;3. Department of radiotherapy, Hopital Nord Franche-Comté de Montbéliard, site du Mittan, 1 rue Henri Becquerel, 25220 Montbéliard, France;4. Department of head and neck surgery, CHU de Besançon, 2, boulevard Fleming, 25030 Besançon, France;5. Department of Maxillofacial Surgery and Stomatology, CHU de Besançon, 2, boulevard Fleming, 25030 Besançon, France;6. Department of head and neck surgery, Hôpital Nord Franche-Comté, 100, route de Moval, Trevenans, France;7. Department of radiotherapy, Centre hospitalier Princesse-Grace, 98000 Monaco, Monaco;8. Centre Hospitalier Universitaire Vaudois, Service de Radio-oncologie, 1005 Lausanne, Switzerland |
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| Abstract: | PurposeRetrospective study to assess the role of radiotherapy (RT) in bladder cancer (BC) in patients who decline cystectomy or for whom it was contraindicated, regarding BC related events.Materials and MethodsA cross-sectional study, of patients with BC treated with RT, with or without chemotherapy was carried out, during the period March 2005 to March 2017, excluding patients who performed cystectomy. BC-related events were defined as haematuria, episodes requiring intravesical irrigations or transurethral resection or admission in Urology Department caused by symptoms related to BC.ResultsFifty-eight patients were included, 44 men and 14 women, whose median age at diagnosis was 78.3 years. Nine patients were treated with a RT dose below 50 Gy (20-45 Gy), in relation with non-resectable disease, nodal involvement, presence of metastasis or poor performance status. Forty-nine patients were treated with a RT dose above 50 Gy (maximum 60.4 Gy). The median follow-up time was 24 months, with BC-specific survival at 1/5 years of 87.5%/0.0% and 83.1%/33.9% in the group treated with RT dose below 50 Gy and above 50 Gy, respectively. Results revealed that the number of events decreased significantly after RT for both groups. For the two groups, the median of events before RT was 2.0, decreasing for 1.0 after RT (RT dose < 50 Gy: P = 0.011; RT dose ≥ 50 Gy: P = 0.026).ConclusionThis therapeutic approach can have an important role in older patients with bladder cancer, in terms of reducing disease related events. Symptom control was significantly achieved in both therapeutic groups. |
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| Keywords: | Cross-Sectional Studies Radiotherapy Treatment Outcome Urinary Bladder Neoplasms Études transversales Radiothérapie Résultat du traitement Néoplasmes de la vessie urinaire |
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