自噬与HMGB1在糖尿病视网膜微血管病变和神经退行性变中的研究进展

糖尿病视网膜病变（diabetic retinopathy，DR）是由糖尿病所导致的最典型的微血管并发症之一。以往DR发病机制和治疗的研究主要集中在微血管；近年来，许多学者认为DR不仅仅是一种微血管病变，而且还伴有视网膜神经退行性变。近期研究表明，自噬与高迁移率族蛋白B1（high mobility group box protein 1，HMGB1）通过多条通路参与到糖尿病视网膜微血管病变和神经退行性变中，通过调控自噬或 HMGB1可能为DR治疗提供一种新的思路。本文就自噬与 HMGB1 在糖尿病视网膜微血管病变和神经退行性变发病中的研究进展进行综述。

Research advances on autophagy and HMGB1 in retinal microangiopathy and neurodegeneration of patient with diabetic retinopathy

Diabetic retinopathy(DR)is one of the most typical microvascular complications caused by diabetes.Previous studies on the pathogenesis and treatment of DR mainly focus on the microangiopathy.In recent years,many researchers hold that DR is not only a microvascular disease,but accompanied by retinal neurodegeneration.Recent studies have shown that autophagy and high mobility group box protein 1(HMGB1)are involved in the microangiopathy and neurodegeneration of DR through multiple pathways,which suggested that regulation of autophagy or HMGB1 may have therapeutic effects on DR.This article reviews the research progress of autophagy and HMGB1 in the microangiopathy and neurodegeneration of DR.