Association between specific plasma ceramides and high-sensitivity C-reactive protein levels in postmenopausal women with type 2 diabetes |
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| Institution: | 1. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;2. Laboratory of Clinical Pharmacology, IRCCS Sacro Cuore–Don Calabria Hospital, Negrar VR, Italy;3. Division of Cardiology, IRCCS Sacro Cuore–Don Calabria’ Hospital, Negrar VR, Italy;4. Section of Clinical Biochemistry, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy;5. Department of endocrinology, Inserm U1018, groupe hospitalier Paris Saint-Joseph, 75014 Paris, France |
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| Abstract: | AimEmerging evidence suggests that specific plasma ceramides are involved in the pathophysiology of cardiovascular disease (CVD) and other inflammation-associated diseases. However, scarce information is currently available on the association between distinct plasma ceramides (that have been associated with increased cardiovascular morbidity and mortality) and plasma high-sensitivity C-reactive protein (hs-CRP) concentrations in patients with type 2 diabetes mellitus (T2DM), a group of individuals at high risk of developing CVD and other chronic inflammation-related conditions.MethodsWe measured six previously identified high-risk plasma ceramide species Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0), Cer(d18:1/24:1)] in 92 postmenopausal women with T2DM attending the diabetes outpatient service over a 3-month period. Plasma ceramide levels were measured using targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay.ResultsPlasma hs-CRP levels were positively associated with all measured ceramides in univariable linear regression analyses. However, only plasma Cer(d18:1/16:0) (standard β coefficient: 0.27, P = 0.015), Cer(d18:1/22:0) (standard β coefficient: 0.25, P = 0.032) and Cer(d18:1/24:1) (standard β coefficient: 0.30, P = 0.007) remained significantly associated with increased plasma hs-CRP levels after adjusting for age, adiposity measures, diabetes duration, HbA1c, insulin resistance, smoking, hypertension, plasma LDL cholesterol, estimated glomerular filtration rate, preexisting ischaemic heart disease and use of lipid-lowering, antihypertensive, antiplatelet or hypoglycaemic drugs.ConclusionIn postmenopausal women with T2DM, elevated levels of specific plasma ceramides are associated with higher plasma hs-CRP levels independent of established cardiovascular risk factors, diabetes-related variables and other potential confounding factors. |
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| Keywords: | Ceramides C-reactive protein Inflammation Type 2 diabetes mellitus Cer"} {"#name":"keyword" "$":{"id":"kw0030"} "$$":[{"#name":"text" "_":"ceramides eGFR"} {"#name":"keyword" "$":{"id":"kw0040"} "$$":[{"#name":"text" "_":"estimated glomerular filtration rate HOMA-IR"} {"#name":"keyword" "$":{"id":"kw0050"} "$$":[{"#name":"text" "_":"homoeostasis model assessment of insulin resistance hs-CRP"} {"#name":"keyword" "$":{"id":"kw0060"} "$$":[{"#name":"text" "_":"high-sensitivity C-reactive protein IHD"} {"#name":"keyword" "$":{"id":"kw0070"} "$$":[{"#name":"text" "_":"ischaemic heart disease NAFLD"} {"#name":"keyword" "$":{"id":"kw0080"} "$$":[{"#name":"text" "_":"non-alcoholic fatty liver disease T2DM"} {"#name":"keyword" "$":{"id":"kw0090"} "$$":[{"#name":"text" "_":"type 2 diabetes mellitus |
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