Impact of thirteen-valent pneumococcal conjugate vaccine on nasopharyngeal carriage in healthy children under 24 months in Okinawa,Japan |
| |
| Affiliation: | 1. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan;2. The Okinawa Society of Child Health, Okinawa, Japan;3. Nakamura Clinic Pediatric, Dermatology and Internal Medicine, Okinawa, Japan;4. Awase Daiichi Clinic, Okinawa, Japan;5. Syuri Child Clinic, Okinawa, Japan;6. Wanpaku Clinic, Okinawa, Japan;1. Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan;2. Department of Clinical Research, National Hospital Organization, Tochigi Medical Center, 1-10-37 Nakatomatsuri, Utsunomiya-city, Tochigi, Japan;3. Department of Infectious Diseases, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan;1. Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;2. Department of Clinical Tropical Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;3. Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan;4. School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan;5. Nijigaoka Hospital, Nagasaki, Japan;6. Nagasaki Kita Hospital, Nagasaki, Japan;7. Nagasaki Rehabilitation Hospital, Nagasaki, Japan;8. Koebaru Chuo Hospital, Nagasaki, Japan;1. Institute of Medical Microbiology, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary;2. Institute of Laboratory Medicine, Semmelweis University, Üllői út 78/a, H-1082 Budapest, Hungary;3. German National Reference Center for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany;4. National Public Health Institute, Albert Flórián út 2-6, H-1097 Budapest, Hungary;1. Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA;2. Pfizer Vaccines Clinical Research and Development, Collegeville, PA, USA;3. Pfizer Vaccines Clinical Research and Development, Pearl River, NY, USA;4. Syneos Health, Princeton, NJ, USA;5. Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA;1. Department of Microbiology, Tokyo Medical University, Tokyo, Japan;2. Department of Clinical Laboratory, Saiseikai Yokohamashi Tobu Hospital, Kanagawa, Japan;3. Department of Bacteriology 1, National Institute of Infectious Diseases, Tokyo, Japan;1. Department of Otorhinolaryngology-Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan;2. Department of Pathology, University of Alabama at Birmingham, UK |
| |
| Abstract: | In November 2013, a 13-valent pneumococcal conjugate vaccine (PCV13) for all infants aged younger than 5 years was incorporated into the Japan national immunization program. An annual survey of nasopharyngeal carriage rates was performed on healthy infants aged 2–24 months from Okinawa, Japan to evaluate the effect of PCV13 on pneumococcal colonization. Of 756 evaluable infants, 203 pneumococcal strains were detected in 193 infants. The overall nasopharyngeal carriage rate was 25.5%, which was not different from our previously reported isolation rate before the introduction of PCV13. The main serotypes of the Streptococcus pneumoniae strains are 15A (18.2%), non-typeable (14.8%), and 15B (11.8%). The carriage rates of pneumococcal strains with 7-valent pneumococcal conjugate vaccine serotypes and PCV13 serotypes were 3.0% and 9.9%, respectively. These values were significantly lower than we reported before the introduction of PCV13. However, the carriage rates of non-PCV13 serotypes have increased. Multivariate logistic regression analysis suggested that siblings and day care attendance are risk factors for pneumococcal carriage. |
| |
| Keywords: | Nasopharynx Carriage Pneumococcal conjugate vaccine Japan Young children PCV13" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" 13-valent pneumococcal conjugate vaccine PCV7" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" heptavalent pneumococcal conjugate vaccine |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
