Radiotherapy of non-tumoral refractory neurological pathologies |
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| Affiliation: | 1. Sorbonne Université, Assistance Publique–Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière–Charles-Foix, Department of Radiation Oncology, 47-83, boulevard de l’Hôpital, 75013 Paris, France;2. Centre Hospitalier Régional Universitaire de Lille, Department of Neurosurgery and Neuro-Oncology, Neurosurgery service, 2, avenue Oscar-Lambret, 59000 Lille, France;3. Lille University, Inserm, U1189-ONCO-THAI-Image Assisted Laser Therapy for Oncology, 1, avenue Oscar-Lambret, 59000 Lille, France;4. Sorbonne Université, Assistance Publique–Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière–Charles-Foix, Department of Neurosurgery, 47-83, boulevard de l’Hôpital, 75013 Paris, France;5. Sorbonne Université, Assistance Publique–Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière–Charles-Foix, Department of Medical Physics, 47-83, boulevard de l’Hôpital, 75013 Paris, France;6. Centre Oscar-Lambret, Academic Department of Radiation Oncology, 3, rue Frédéric-Combemale, 59000 Lille, France;7. Lille University, Centre de Recherche en Informatique, Signal et Automatique de Lille, CRIStAL UMR 9189, Scientific Campus, bâtiment Esprit, avenue Henri-Poincaré, 59655 Villeneuve-d’Ascq, France;1. Département de radiothérapie, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France;2. Département d’oncologie médicale, centre Henri-Becquerel, 1, rue d’Amiens, 76038 Rouen, France;3. Département d’oncologie médicale, centre François-Baclesse, 3, avenue General-Harris, 14000 Caen, France;4. Département de radiothérapie, hôpital Nord-Franche-Comté, site du Mittan, 1, rue Henri-Becquerel, 25209 Montbéliard, France;5. Département de radiothérapie, centre François-Baclesse, 3, avenue General-Harris, 14000 Caen, France;6. Association Advance Resource Centre for Hadrontherapy in Europe (Archade), 3, avenue General-Harris, 14000 Caen, France;1. Département de radiothérapie-oncologique, hôpital universitaire Gustave-Roussy, université Paris Saclay, 114, rue Édouard-Vaillant, 94805 Villejuif, France;2. Département de radiothérapie-oncologique, centre Paul-Strauss, 3, rue de la-Porte-de-l’Hôpital, 67065 Strasbourg, France;3. Université de Strasbourg, CNRS, IHPC UMR 7178, centre Paul-Strauss, 67000 Strasbourg, France;4. Département de radiothérapie-oncologique, institut Paoli-Calmettes, 232, boulevard Sainte-Marguerite, 13273 Marseille 09, France;5. CRCM, institut Paoli-Calmettes, 232, boulevard Sainte-Marguerite, 13273 Marseille 09, France;1. CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France;2. Service de radiothérapie, CHRU de Brest, 2, avenue Foch, 29609 Brest cedex, France;1. Department of radiation oncology, centre Henri-Becquerel, 1, rue d’Amiens, 76000 Rouen, France;2. Département de chirurgie, centre Henri-Becquerel, 1, rue d’Amiens, 76000 Rouen, France;3. Department of radiation oncology, centre François-Baclesse, 3, avenue du General-Harris, 14000 Caen, France;4. Department of radiation oncology. Gustave-Roussy Cancer Campus, Université Paris-Sud, 114, rue Édouard-Vaillant, 94805 Villejuif, France;1. Service de radiothérapie, Institut de cancérologie de l’Ouest, centre René-Gauducheau, boulevard Jacques-Monod, 44800 Saint-Herblain, France;2. Service de radiothérapie, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France;3. Fédération Claude-Lalanne, université Côte d’Azur, 33, avenue de Valombrose, 06189 Nice, France;4. Université de Nantes, Institut de recherche en santé de l’université de Nantes, 8, quai Moncousu, BP 70721, 44007 Nantes cedex 1, France;5. Inserm, U1232 Centre de recherche en cancérologie et immunologie de Nantes-Angers (CRCINA), 8, quai Moncousu, BP 70721, 44007 Nantes cedex 1, France;6. CNRS, ERL 6001, 8, quai Moncousu, BP 70721, 44007 Nantes cedex 1, France;1. Health Data Hub, 9, rue Georges-Pitard, 75015 Paris, France;2. LPC-IN2P3 ENSICAEN/CNRS UMR 6534, 6, boulevard du Maréchal-Juin, 14050 Caen cedex, France |
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| Abstract: | Intracranial radiotherapy has been improved, primarily because of the development of stereotactic approaches. While intracranial stereotactic body radiotherapy is mainly indicated for treatment of benign or malignant tumors, this procedure is also effective in the management of other neurological pathologies; it is delivered using GammaKnife® and linear accelerators. Thus, brain arteriovenous malformations in patients who are likely to experience permanent neurological sequelae can be managed by single session intracranial stereotactic body radiotherapy, or radiosurgery, in specific situations, with an advantageous benefit/risk ratio. Radiosurgery can be recommended for patients with disabling symptoms, which are poorly controlled by medication, such as trigeminal neuralgia, and tremors, whether they are essential or secondary to Parkinson's disease. This literature review aims at defining the place of intracranial stereotactic body radiotherapy in the management of patients suffering from non-tumoral refractory neurological pathologies. It is clear that the multidisciplinary collaboration of experienced teams from Neurosurgery, Neurology, Neuroradiology, Radiation Oncology and Medical Physics is needed for the procedures using high precision radiotherapy techniques, which deliver high doses to locations near functional brain areas. |
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| Keywords: | Radiotherapy Arteriovenous malformations Trigeminal neuralgia Tremor Radiothérapie Malformations artérioveineuses Névralgie faciale Tremblement |
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