Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort |
| |
| Institution: | 1. Centre de Recherche des Cordeliers, Inserm UMR-S 1138, 15 rue de l’école de Médecine, 75006 Paris, France;2. Université de Paris, UMR-S 1138, 15 rue de l’école de Médecine, 75006 Paris, France;3. Sorbonne Université, 15 rue de l’école de Médecine, 75006 Paris, France;4. AP–HP, Biochemistry and Hormonology Department, Tenon Hospital, 4 Rue de la Chine, 75020 Paris, France;5. Vital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland;6. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland;7. Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Université de Paris, 4 rue Marie-Andrée Lagroua Weill Hallé, 75013 Paris, France;8. UMR 9198 Institut des Neurosciences Paris Saclay (Neuro-PSI), Université Paris-Sud, Université Paris-Saclay, bâtiment 447, 91405 Orsay cedex, France;9. Diabetology, Endocrinology, Nutrition, APHP - Bichat Hospital, 46 rue Henri Huchard, 75018 Paris, France;10. Centre for Research in Epidemiology and Population Health (CESP), INSERM, UMR-S 1018, University Paris-Sud, University Versailles Saint-Quentin, 16 av. Paul Vaillant Couturier 94800 Villejuif, France |
| |
| Abstract: | AimIn the D.E.S.I.R. cohort, higher consumption of dairy products was associated with lower incidence of hyperglycaemia, and dihydroceramide concentrations were higher in those who progressed to diabetes. Our aim here was to study the relationships between dairy consumption and concentrations of dihydroceramides and ceramides.MethodsIn the D.E.S.I.R. cohort, men and women aged 30–65 years, volunteers from West-Central France, were included in a 9-year follow-up with examinations every 3 years, including food-frequency questionnaires. Two items concerned dairy products (cheese, other dairy products except cheese). At each examination, dihydroceramides and ceramides were determined by mass spectrometry in a cohort subset; in the present study, the 105 people who did not progress to type 2 diabetes were analyzed, as the disorder per se might be a confounding factor.ResultsHigher consumption of dairy products (except cheese) was associated with total plasma dihydroceramides during the follow-up, but only in women (P = 0.01 for gender interaction). In fact, dihydroceramide levels were lower in women with high vs low consumption (P = 0.03), and were significantly increased during follow-up (P = 0.01) in low consumers only. There was also a trend for lower ceramides in women with high dairy (except cheese) intakes (P = 0.08). Cheese was associated with dihydroceramide and ceramide changes during follow-up (P = 0.04 for both), but no clear trend was evident in either low or high consumers.ConclusionThese results show that, in women, there is an inverse association between fresh dairy product consumption and predictive markers (dihydroceramides) of type 2 diabetes. |
| |
| Keywords: | Ceramides Dairy product intake Dihydroceramides General population Longitudinal study |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
