Melatonin and ulceration in rat stomach in acute emotional stress |
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Authors: | S S Pertsov A S Sosnovskii G V Pirogova |
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Institution: | (1) P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | Formation of peptic ulcers under conditions of acute emotional stress was studied in rats injected with different doses of
melatonin (0.5, 1, and 2 mg/kg). The number of total length of peptic ulcers increases under conditions of stress. In unstressed
rats melatonin induces ulceration of gastric mucosa. In a dose of 1 mg/kg melatonin exerts protective effect on gastric mucosa.
No significant changes in the number and total length of peptic ulcers are noted with 0.5 and 2 mg/kg melatonin.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 1, pp. 12–14, January, 1998 |
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Keywords: | emotional stress melatonin peptic ulcer |
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