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| γ-亚麻酸乙酯的合成研究 | |
| 引用本文： | 郭义明,王虹,郭宇. γ-亚麻酸乙酯的合成研究[J]. 中国生化药物杂志, 2004, 25(2): 88-90 |
| 作者姓名： | 郭义明 王虹 郭宇 |
| 作者单位： | 1. 吉林省人民医院,吉林,长春,130012 2. 吉林大学,第一临床学院,吉林,长春,130021 3. 长春长生基因药业有限公司,吉林,长春,130010 |
| 摘 要： | 目的确定合成γ 亚麻酸乙酯的最佳工艺路线。方法以黑加仑油为原料采用尿素包和、柱色谱法、酸催化法等联合方法分离及合成γ 亚麻酸乙酯。结果确定黑加仑油经 2～ 3次尿素包和 ,反应温度 80℃ ,反应时间90min ,3%盐酸作酸性溶媒 ,乙醇和γ 亚麻酸比例为 3∶1的制备工艺。结论酸催化法合成γ 亚麻酸乙酯工艺简便 ,易于操作 ,产品收率高、稳定性好。 |
| 关 键 词： | 黑加仑油 γ-亚麻酸 γ-亚麻酸乙酯 分离 合成 |
| 文章编号： | 1005-1678(2004)02-0088-03 |
| 修稿时间： | 2003-05-19 |
Synthesis research on γ-linolenic acid ethyl |
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| GUO Yi-ming,WANG Hong,GUO Yu. Synthesis research on γ-linolenic acid ethyl[J]. Chinese Journal of Biochemical Pharmaceutics, 2004, 25(2): 88-90 | |
| Authors: | GUO Yi-ming WANG Hong GUO Yu |
| Affiliation: | GUO Yi-ming1,WANG Hong2,GUO Yu3 |
| Abstract: | PurposeTo optimize synthetical route of γ-linolenic acid ethyl.MethodsUsing a united technology of carbamide encapsulation,column chromatography, acid catalysis technique etc. to separate and syn-thesize γ-linolenic acid ethyl from Ribes nigrum L. seed oil.ResultsThe optimum synthetical conditions of γ-linolenic acid ethyl were as follows: the temperature was 80℃,the duration was 90 min, the catalyzer was 3%hydrochloric acid, and the proportion of ethanol and γ-linolenic acid was 3∶1.ConclusionThis kind of synthesis technique of γ-linolenic acid ethyl provides briefness and convenience to operate,the synthesis rate of the offspring is high and the offspring is stabilized. |
| Keywords: | Ribes nigrum L. seed oil γ-linolenic acid γ-linolenic acid ethyl separation synthesis |
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