胱抑素C与髓过氧化物酶在冠心病严重程度评估中的应用

目的研究分析冠心病病变程度与白细胞计数、超敏C反应蛋白(CRP)、纤维蛋白原(FG)、髓过氧化物酶、胱抑素C、肌酐(Scr)、肾小球滤过率(eGFR)之间的关系。方法收集121例冠脉造影后有冠状动脉狭窄患者(男86例,女35例)的临床资料及静脉血,根据临床诊断结果分为急性冠脉综合症组(ACS)和稳定性心绞痛组(SAP),以同期50例体检者作为健康对照组,检测患者组及健康组白细胞计数、超敏CRP、FG、髓过氧化物酶、胱抑素C、Scr、eGFR,统计分析各组间的关系。结果(1)SAP组白细胞计数、超敏CRP、FG、髓过氧化物酶、胱抑素C、eGFR水平较健康组有增高,差异有统计学意义(P0.05);(2)ACS组FG、中性粒细胞、单核细胞、超敏CRP、髓过氧化物酶、胱抑素C、eGFR水平明显高于SAP组,差异有统计学意义(P0.05),而白细胞计数、Scr水平差异均无统计学意义(P0.05);(3)ACS组(1.42±0.46)mg/L、SAP组(0.93±0.29)mg/L,与健康对照组之间胱抑素C(0.78±0.37)mg/L,比较差异有统计学意义(P0.05)。结论白细胞计数、超敏CRP、FG、髓过氧化物酶、胱抑素C、eGFR与冠心病病变程度密切相关,尤其是超敏CRP、胱抑素C。对于早期发现冠心病,监视冠心病病程,对急性冠脉综合征与稳定性心绞痛区分有意义。

Application of the laboratory items in detection of the severity of coronary heart disease

Objective To study the relationship between the extent of coronary heart disease and the white blood cell count,C-reactive protein,fibrinogen,myeloperoxidase,cystatin C,creatinine,and the rate of glomerular filtration.Methods The clinical data and blood of 121 cases of patients with coronary artery stenosis(86 cases of male and 35 cases of female) were collected,and devided them into the acute coronary syndrome group(ACS) and stable angina group(SAP) according to the clinical diagnosis,while 50 cases of phy...