乌司他丁对婴儿体外循环中细胞粘附分子变化的影响

目的:探讨婴儿体外循环中细胞粘附分子的变化及乌司他丁对其的影响。方法:60例1岁以下先心病患儿随机分为乌司他丁组(U组,UTI20000U/kg,溶解于20ml生理盐水中)和对照组(C组,20ml等量生理盐水)。分别在体外循环不同时点采集血样,检测血管内皮细胞粘附分子-1(ICAM-1)和中性粒细胞整合素β-2亚族中的CD11b/CD18的蛋白表达量并观察其变化;检测血气值并计算呼吸指数(RI)。结果:体外循环后两组ICAM-1和CD11b/CD18的表达量均显著增加,RI上升,但乌司他丁组各相应值明显低于对照组(P<0.05)。结论:婴儿体外循环中,ICAM-1、CD11b/CD18和RI值均有明显升高,乌司他丁可减缓此变化过程。

Ulinastatin impacts the changes of cell adhesion molecules during infant cardiopulmonary bypass

Objective:To investigate the changs of cell adhesion molecules and observe the influence with ulinastatin during the infant cardiopulmonary bypass. Methods:Sixty infants with congenital heart disease were randomly divided into two groups:group U(received ulinastatin 20 000 U/kg,dissolved in 20 ml normal saline),group C(received 20 ml normal saline). Blood samples were collected in different moments. The proteinum expressions of ICAM-1 and CD11b/CD18 were examined,and the variations were observed. The blood gas value and calculated respiratory index(RI) were also detected. Results:The expressions of ICAM-1 and CD11b/CD18 increased significantly after CPB in two groups with RI rising,and increased more obviously in group C than those in group U(P < 0.05). Conclusion:The expressions of ICAM-1 and CD11b/CD18 increased,and RI rose during the CPB in infant. Ulinastatin may relieve the process.