Effects of opioid peptides on the development of ischemic cardiac arrhythmias under conditions of partial sympathetic denervation and laser irradiation

The effects of intravenous administration of different opioid peptides on the development of ischemic cardiac arrhythmias under conditions of intraatrial laser irradiation (λ=632.8 nm) were studied in cats with transected cardiac branches of the right stellate ganglion and preserved sympathetic innervation of the ischemized area. Ischemia was caused by occlusion of the circumflex branch of the left coronary artery. It was found that the protective effects of dalargin were most powerful when sympathetic influences on the ischemic area were intestified by laser irradiation. Under these conditions DAGO showed more pronounced antiarrhythmic effects than DSLET. Translated fromByulleten' Eksperimental'noi Biologii i Medistiny, Vol. 127, No. 4, pp. 374–377, April, 1999