麻姜宣肺胶囊药效学研究

目的： 观察麻姜宣肺胶囊的镇咳、祛痰、抗炎、解热和平喘作用。 方法： 将小鼠随机分为空白组、阳性药组和麻姜宣肺胶囊的高、中、低剂量组（2.49，1.24，0.62 g·kg^-1），ig 7 d，分别采用氨水法、酚红法和小鼠耳肿胀法对麻姜宣肺胶囊的镇咳、祛痰、抗炎作用进行研究。将大鼠随机分为空白组、阳性药组、模型组和麻姜宣肺胶囊高、中、低剂量组（1.8，0.9，0.45 g·kg^-1），采用内毒素致热实验观察其解热作用。将豚鼠随机分为空白组、阳性药组和麻姜宣肺胶囊的高、中、低剂量组（1.55，0.77，0.39 g·kg^-1），采用整体动物引喘实验观察其平喘作用。 结果： 麻姜宣肺胶囊高、中剂量可减少小鼠咳嗽次数，延长咳嗽潜伏期（P<0.05，P<0.01）；高剂量能增加小鼠呼吸道酚红排泌量（P<0.01）；高、中、低剂量可抑制二甲苯所致的小鼠耳肿胀度（P<0.05）；高剂量可抑制脂多糖所致的大鼠体温升高（P<0.05，P<0.01）；高剂量可延长豚鼠乙酰胆碱和磷酸组胺所致的引喘潜伏期（P<0.05，P<0.01）。 结论： 麻姜宣肺胶囊具有镇咳、祛痰、抗炎、解热和平喘的作用。

Pharmacodynamics Research of Majiang Xuanfei Capsule

Objective: To study the effect of Majiang Xuanfei capsule on antitussive, expectorant, anti-inflammatory, antipyretic and antiasthmatic activities. Method: Mice were randomly divided into 5 groups:normal control group, positive group, Majiang Xuanfei capsule high dose, middle dose and low dose groups(2.49, 1.24, 0.62 g·kg^-1). After 7 days of ig administration,aqueous ammonia, phenol red, mouse ear swelling, expectorant were used to study the dosage-effect relation of Majiang Xuanfei capsule in mice. Rats were randomly divided into blank group, positive medicine group, model group and Majiang Xuanfei capsule high, medium and low dose groups (1.8, 0.9, 0.45 g·kg^-1). The antipyretic activity of Majiang Xuanfei capsule was observed by endotoxin in rats. Guinea pigs were randomly divided into blank group, positive medicine group and Majiang Xuanfei capsule high, medium and low dose groups (1.55, 0.77, 0.39 g·kg^-1). The antiasthma effect of Majiang Xuanfei capsule was studied by the asthma time induced by acetylcholine chloride and histamine phosphate in guinea pigs. Result: Majiang Xuanfei capsule could reduce the frequency of cough induced by ammonia and prolong the latent period of cough (P<0.05, P<0.01). High dose could increase the phenol red excretion of respiratory tract in mice (P<0.01).High, medium and low dose could inhibit the mouse ear swelling induced by xylene (P<0.05). High dose could inhibit the temperature in rats induced by fat polysaccharide (P<0.05, P<0.01) and prolong the asthma time induced by acetylcholine chloride and histamine phosphate in guinea pigs (P<0.05, P<0.01). Conclusion: Majiang Xuanfei capsule has antitussive, expectorant, anti-inflammatory, antipyretic, and antiasthmatic activities.